Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

被引：69
作者：
Guo, Zijing [1 ,2 ]
Zhang, Zhidong [2 ]
Prajapati, Meera [2 ,3 ]
Li, Yanmin [2 ]
机构：
[1] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730030, Peoples R China
[2] Southwest Minzu Univ, Coll Anim Husb & Vet Med, Chengdu 610041, Peoples R China
[3] Nepal Agr Res Council, Natl Anim Hlth Res Ctr, Lalitpur 44700, Nepal
来源：
VIRUSES-BASEL | 2021年 / 13卷 / 09期
关键词：
lymphopenia; viruses; apoptosis; cytokines; immune response; INDUCED CELL-DEATH; PERIPHERAL-BLOOD LYMPHOCYTES; ACUTE RESPIRATORY SYNDROME; T-CELL; DENDRITIC CELLS; EBOLA-VIRUS; IMMUNE-RESPONSE; PHENOTYPIC CHARACTERIZATION; CORONAVIRUS INFECTION; APOPTOSIS INDUCTION;
D O I：
10.3390/v13091876
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.
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页数：18
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共 184 条
[1]   Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review [J].
Abrantes, Joana ;
van der Loo, Wessel ;
Le Pendu, Jacques ;
Esteves, Pedro J. .
VETERINARY RESEARCH, 2012, 43
[2]   NORWALK VIRUS OUTBREAK AT A COLLEGE CAMPUS [J].
ALEXANDER, WJ ;
HOLMES, JR ;
SHAW, JFE ;
RILEY, WE ;
ROPER, WL .
SOUTHERN MEDICAL JOURNAL, 1986, 79 (01) :33-36
[3]  
[Anonymous], [No title captured], DOI [10.1016/S2213-2600(20)30079-5, DOI 10.1016/S2213-2600(20)30328-3]
[4]   Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J].
Assiri, Abdullah ;
Al-Tawfiq, Jaffar A. ;
Al-Rabeeah, Abdullah A. ;
Al-Rabiah, Fahad A. ;
Al-Hajjar, Sami ;
Al-Barrak, Ali ;
Flemban, Hesham ;
Al-Nassir, Wafa N. ;
Balkhy, Hanan H. ;
Al-Hakeem, Rafat F. ;
Makhdoom, Hatem Q. ;
Zumla, Alimuddin I. ;
Memish, Ziad A. .
LANCET INFECTIOUS DISEASES, 2013, 13 (09) :752-761
[5]   Progressive multifocal leukoencephalopathy secondary to hepatitis C virus infection-related T-cell lymphopenia [J].
Aung, Ar Kar ;
Robinson, Jessica ;
Hey, Penelope ;
Lehmann, Mahalia ;
Chow, Yan ;
Stark, Richard J. ;
Bosco, Julian J. .
INTERNAL MEDICINE JOURNAL, 2019, 49 (01) :114-118
[6]   CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses [J].
Barouch, DH ;
Letvin, NL .
CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) :479-482
[7]   Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV) [J].
Bautista, EM ;
Ferman, GS ;
Golde, WT .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2003, 92 (1-2) :61-73
[8]   Pathogenesis and immunopathology of systemic and nervous canine distemper [J].
Beineke, A. ;
Puff, C. ;
Seehusen, F. ;
Baumgaertner, W. .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2009, 127 (1-2) :1-18
[9]   Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients [J].
Bellesi, Silvia ;
Metafuni, Elisabetta ;
Hohaus, Stefan ;
Maiolo, Elena ;
Marchionni, Federica ;
D'Innocenzo, Simone ;
La Sorda, Marilena ;
Ferraironi, Manuela ;
Ramundo, Francesco ;
Fantoni, Massimo ;
Murri, Rita ;
Cingolani, Antonella ;
Sica, Simona ;
Gasbarrini, Antonio ;
Sanguinetti, Maurizio ;
Chiusolo, Patrizia ;
De Stefano, Valerio .
BRITISH JOURNAL OF HAEMATOLOGY, 2020, 191 (02) :207-211
[10]   Atrophy of primary lymphoid organs induced by Marek's disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia [J].
Berthault, Camille ;
Larcher, Thibaut ;
Haertle, Sonja ;
Vautherot, Jean-Francois ;
Trapp-Fragnet, Laetitia ;
Denesvre, Caroline .
VETERINARY RESEARCH, 2018, 49
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