Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility

被引:705
作者
Garlanda, C
Bottazzi, B
Bastone, A
Mantovani, A
机构
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] Univ Milan, Fac Med, Inst Gen Pathol, Milan, Italy
关键词
inflammatory response; immune response; extracellular matrix; fertility; neurodegeneration;
D O I
10.1146/annurev.immunol.23.021704.115756
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, including the prototype PTX3, are expressed in a variety of tissues. Some long pentraxins are expressed in the brain and some are involved in neuronal plasticity and degeneration. PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to Toll-like receptor (TLR) engagement and inflammatory cytokines. PTX3 acts as a functional ancestor of antibodies, recognizing microbes, activating complement, and facilitating pathogen recognition by phagocytes, hence playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility because it acts as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
引用
收藏
页码:337 / 366
页数:30
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