Bronsted acid ionic liquid-catalyzed reductive Friedel-Crafts alkylation of indoles and cyclic ketones without using an external reductant

被引：108

作者：

Taheri, Amir ^{[1
]}

Lai, Bingbing ^{[1
]}

Cheng Chenga ^{[1
]}

Gu, Yanlong ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Large Format Battery Mat & Syst, Minist Educ, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

[2] Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

GREEN CHEMISTRY | 2015年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

VIRUS NS5B POLYMERASE; ALLOSTERIC INHIBITORS; DISCOVERY; ALCOHOLS; HCV; BENZIMIDAZOLE; DELEOBUVIR;

D O I：

10.1039/c4gc01299b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the absence of an external reductant, C3-cycloalkylated indole could be synthesized through reductive alkylation of indole with cyclic ketone using a sulfonyl-functionalized Bronsted acid ionic liquid as a catalyst. Water generated in the initial stage of the reaction played a key role in rendering the reductive coupling possible. The reaction proceeds most likely in a radical way.

引用

页码：812 / 816

页数：5