Bronsted acid ionic liquid-catalyzed reductive Friedel-Crafts alkylation of indoles and cyclic ketones without using an external reductant

被引：106
|
作者：
Taheri, Amir [1 ]
Lai, Bingbing [1 ]
Cheng Chenga [1 ]
Gu, Yanlong [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Large Format Battery Mat & Syst, Minist Educ, 1037 Luoyu Rd, Wuhan 430074, Peoples R China
[2] Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
来源：
GREEN CHEMISTRY | 2015年 / 17卷 / 02期
基金：
中国国家自然科学基金;
关键词：
VIRUS NS5B POLYMERASE; ALLOSTERIC INHIBITORS; DISCOVERY; ALCOHOLS; HCV; BENZIMIDAZOLE; DELEOBUVIR;
D O I：
10.1039/c4gc01299b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the absence of an external reductant, C3-cycloalkylated indole could be synthesized through reductive alkylation of indole with cyclic ketone using a sulfonyl-functionalized Bronsted acid ionic liquid as a catalyst. Water generated in the initial stage of the reaction played a key role in rendering the reductive coupling possible. The reaction proceeds most likely in a radical way.
引用
收藏
页码：812 / 816
页数：5
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