New terpenoids, olibanumols D-G, from traditional Egyptian medicine olibanum, the gum-resin of Boswellia carterii

被引:28
|
作者
Morikawa, Toshio [1 ,2 ]
Oominami, Hideo [1 ]
Matsuda, Hisashi [1 ]
Yoshikawa, Masayuki [1 ]
机构
[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan
[2] Kinki Univ, Pharmaceut Res & Technol Inst, Osaka 5778502, Japan
关键词
Olibanumol; Olibanum; Boswellia carterii; Nitric oxide production inhibitory activity; Burseraceae; NITRIC-OXIDE PRODUCTION; INHIBITORS;
D O I
10.1007/s11418-010-0472-z
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new prenylaromadendrane-type diterpene, olibanumol D (1), and three new oleanane- and lupane-type triterpenes, olibanumols E (2), F (3), and G (4), were isolated from the traditional Egyptian medicine olibanum, the exuded gum-resin from Boswellia carterii Birdw. Their structures were established mainly on the basis of 1D and 2D NMR spectral data. Compounds 1 and 2 exhibited nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse peritoneal macrophages.
引用
收藏
页码:129 / 134
页数:6
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