Electro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal fos protein expression in rats with persistent inflammation

被引:48
作者
Lao, LX
Zhang, G
Wei, F
Berman, BM
Ren, K
机构
[1] Univ Maryland, Sch Med, Complementary Med Program, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Dent, Dept Oral & Craniofacial Biol Sci, Baltimore, MD 21201 USA
基金
美国国家卫生研究院;
关键词
acupuncture; Freund's adjuvant; analgesia; pain modulation;
D O I
10.1054/jpai.2001.19575
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This study examined the effect of electro-acupuncture (EA) on persistent inflammatory hyperalgesia in a rat model. Inflammation and hyperalgesia were induced by injecting complete Freund's adjuvant (CFA) into one hindpaw of the rat. Hyperalgesia was determined by a decrease in paw withdrawal latencies (PWL) to a noxious thermal stimulus. EA was applied bilaterally at the acupuncture point Huantiao (G30) at the rat's hindlimbs. EA-treated rats (n = 11) had significantly longer PWLs as compared with placebo control rats (n = 7) in the inflamed paw at 2.5 hours and 5 days after injection of CFA (P < .05) and longer PWLs as compared to sham control rats (n = 9) at 2.5 hours (P > .05). Paw edema was significantly reduced in EA-treated rats versus placebo controls at 24 hours after inflammation (P < 01). inflammation-induced spinal Fos expression in the medial half of laminae I-II in EA-treated rats versus placebo rats (0 = 5 per group) was significantly reduced (P < .01). These data showed that EA delayed the onset and facilitated the recovery of inflammatory hyperalgesia and suppressed the inflammation-induced spinal Fos expression in neurons (laminae I-II) involved in receiving noxious stimulation. This rat model of persistent pain and inflammation seems to be an ideal animal model for studying the effect of acupuncture.
引用
收藏
页码:111 / 117
页数:7
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