Type 1 diabetes as a relapsing-remitting disease?

被引：191

作者：

von Herrath, Matthias

Sanda, Srinath

Herold, Kevan

机构：

[1] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA

[2] Benaroya Res Inst, Seattle, WA 98101 USA

[3] Yale Univ, Sch Med, New Haven, CT 06509 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 12期

关键词：

D O I：

10.1038/nri2192

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic immunological processes that underlie persistent viral infections and autoimmune disorders such as multiple sclerosis can be relapsing - remitting in nature. The progressive loss of beta-cell mass during the development of autoimmune type 1 diabetes ( T1D) can also be non - linear, but the exact nature and kinetics of the immunological processes that govern T1D are not known. Here, we propose that the immunological process that is at the root of T1D is relapsing remitting in nature and discuss the unresolved controversies and therapeutic implications of this hypothesis.

引用

收藏

页码：988 / 994

页数：7

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