A micro-planar amperometric glucose sensor unsusceptible to interference species

The development of an amperometric glucose sensor in which a hydrogen peroxide detecting platinum electrode is coated with gamma-APTES, acetylcellulose, Nafion(R), glucose oxidase, and polydimethylsiloxane to prevent interference species is reported here. Tests of the sensor demonstrate its imperviousness to the effects of ascorbic acid (< 11 mM), uric acid (< 0.3 mM), and p-acetaminophen (< 0.4 mM), as well as its ability to measure glucose concentrations ranging from 0.6 to 278 mM, and its capacity to reach steady-state response within 10 s. Furthermore, in tests on diabetic urine samples, the correlation coefficient between the glucose sensor and a clinical analyzer was good: 0.924 (y = 0.935x + 0.564, n = 37). (C) 1998 Elsevier Science S.A. All rights reserved.