The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats

被引:13
作者
Chang, Ting-Kuo [1 ,2 ,3 ]
Huang, Chang-Hung [2 ]
Huang, Chun-Hsiung [1 ,2 ,3 ]
Chen, Hsuan-Chiang [2 ]
Cheng, Cheng-Kung [1 ]
机构
[1] Natl Yang Ming Univ, Inst Biomed Engn, Taipei 112, Taiwan
[2] Mackay Mem Hosp, Biomech Lab, Dept Med Res, Taipei, Taiwan
[3] Mackay Mem Hosp, Dept Orthopaed Surg, Taipei, Taiwan
来源
BMC MUSCULOSKELETAL DISORDERS | 2010年 / 11卷
关键词
YOUNG GROWING RATS; CANCELLOUS BONE; MINERAL DENSITY; OSTEOARTHRITIS; MODEL; REPLACEMENT; METABOLISM; ESTROGEN; CALCIUM;
D O I
10.1186/1471-2474-11-185
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: Loss of bone quality and deterioration of articular cartilage are commonly seen after menopause. While exercise may protect against tissue degeneration, a clear link has yet to be established. The aim of the present study is to investigate the influence of long-term treadmill exercise on changes in bone mass and articular cartilage in ovariectomized rats. Methods: Sixty female Sprague-Dawley rats were randomly assigned to 4 groups: ovariectomized (OVX), ovariectomized plus treadmill exercise (OVX-RUN), treadmill exercise alone (RUN), and control (CON) groups. After 36 weeks, the following variables were compared among the 4 groups. Bone mass was evaluated by trabecular bone volume and bone mineral density (BMD). Articular cartilage in the knee joints was evaluated by histology analysis and a modified Mankin score. Results: Rats in the ovariectomized groups (OVX and OVX-RUN) had significantly lower BMD and bone mass than the non-ovariectomized rats (CON and RUN), indicating that exercise did little to preserve bone mass. However, the sedentary OVX group had a significantly worse modified Mankin score (7.7 +/- 1.4) than the OVX-RUN group (4.8 +/- 1.0), whose scores did not differ significantly from the other 2 non-operated groups. The articular cartilage in the sedentary OVX rats was relatively thinner, hypocellular, and had more clefts than in the other 3 groups. Conclusion: This study suggests that long-term exercise protects articular cartilage in OVX rats but does not retard the loss of bone mass seen in after menopause.
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页数:7
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