Long-term response to highly active antiretroviral therapy in human immunodeficiency virus and hepatitis C virus coinfected children -: 6 years of follow-up

被引：4

作者：

Micheloud, Dariela

Jensen, Julia

Bellon, Jose M.

Gonzalez, Raul

Mellado, M. Jose

Navarro, Luisa

Munoz-Fernandez, Angeles

Resino, Salvador

机构：

[1] Hosp Gen Univ Gregorio Maranon, Lab Immunobiol Mol, Madrid 28007, Spain

[2] Hosp Univ Hosp St Joan dAlacant, Alicante, Spain

[3] Hosp Univ Carlos III, Madrid, Spain

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2007年 / 26卷 / 11期

关键词：

HAART; CD4+; viral load; immune reconstitution; hepatic enzymes; toxicity;

D O I：

10.1097/INF.0b013e31812e531c

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

WE carried out a retrospective study to analyze the long-term response to highly active antiretroval therapy of 19 vertically human immunodeficiency virus type 1/hepatitis C virus (HCV-1/HIV) coinfected children. The clinical, immunologic, viral, and biochemical variables were assayed at 0, 1, 2, 3, 4, 5, and 6 years of follow-up. Our data suggest that CD4(+) T-cell recovery and viral load control during long-term highly active antiretroviral therapy among HIV-1/HCV children, but hepatic function was significantly altered in HIV-1/HCV children. (C) 2007 Lippincott Williams & Wilkins

引用

页码：1061 / 1064

页数：4

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