An Imagable and Photothermal "Abraxane-Like" Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors

被引：435

作者：

Chen, Qian ^{[1
]}

Liang, Chao ^{[1
]}

Wang, Chao ^{[1
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 05期

基金：

中国国家自然科学基金;

关键词：

human serum albumin; indocyanine green; paclitaxel; combination therapy; lung metastasis; IN-VIVO; INDOCYANINE GREEN; CARBON NANOTUBES; GRAPHENE OXIDE; NONCODING RNA; DRUG CARRIER; NANOPARTICLES; ALBUMIN; DELIVERY; PACLITAXEL;

D O I：

10.1002/adma.201404308

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-ofconcept study.

引用

页码：903 / 910

页数：8

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