An Imagable and Photothermal "Abraxane-Like" Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors

被引：429
作者：
Chen, Qian [1 ]
Liang, Chao [1 ]
Wang, Chao [1 ]
Liu, Zhuang [1 ]
机构：
[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 05期
基金：
中国国家自然科学基金;
关键词：
human serum albumin; indocyanine green; paclitaxel; combination therapy; lung metastasis; IN-VIVO; INDOCYANINE GREEN; CARBON NANOTUBES; GRAPHENE OXIDE; NONCODING RNA; DRUG CARRIER; NANOPARTICLES; ALBUMIN; DELIVERY; PACLITAXEL;
D O I：
10.1002/adma.201404308
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-ofconcept study.
引用
收藏
页码：903 / 910
页数：8
相关论文
共 43 条
  • [1] [Anonymous], 2011, Angewandte Chemie
  • [2] Bocci G, 2002, CANCER RES, V62, P6938
  • [3] Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity
    Boisselier, Elodie
    Astruc, Didier
    [J]. CHEMICAL SOCIETY REVIEWS, 2009, 38 (06) : 1759 - 1782
  • [4] An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery
    Chen, Qian
    Liang, Chao
    Wang, Xin
    He, Jingkang
    Li, Yonggang
    Liu, Zhuang
    [J]. BIOMATERIALS, 2014, 35 (34) : 9355 - 9362
  • [5] Nanoparticle therapeutics: an emerging treatment modality for cancer
    Davis, Mark E.
    Chen, Zhuo
    Shin, Dong M.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) : 771 - 782
  • [6] Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo
    Dong, Kai
    Liu, Zhen
    Li, Zhenhua
    Ren, Jinsong
    Qu, Xiaogang
    [J]. ADVANCED MATERIALS, 2013, 25 (32) : 4452 - 4458
  • [7] Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery
    Feng, Liangzhu
    Yang, Xianzhu
    Shi, Xiaoze
    Tan, Xiaofang
    Peng, Rui
    Wang, Jun
    Liu, Zhuang
    [J]. SMALL, 2013, 9 (11) : 1989 - 1997
  • [8] Detection of melamine using commercial enzyme-linked immunosorbent assay technology
    Garber, Eric A. E.
    [J]. JOURNAL OF FOOD PROTECTION, 2008, 71 (03) : 590 - 594
  • [9] Metal-enhanced fluorescence (MEF) due to silver colloids on a planar surface: Potential applications of indocyanine green to in vivo imaging
    Geddes, CD
    Cao, H
    Gryczynski, I
    Gryczynski, Z
    Fang, JY
    Lakowicz, JR
    [J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2003, 107 (18) : 3443 - 3449
  • [10] Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    Gupta, Rajnish A.
    Shah, Nilay
    Wang, Kevin C.
    Kim, Jeewon
    Horlings, Hugo M.
    Wong, David J.
    Tsai, Miao-Chih
    Hung, Tiffany
    Argani, Pedram
    Rinn, John L.
    Wang, Yulei
    Brzoska, Pius
    Kong, Benjamin
    Li, Rui
    West, Robert B.
    van de Vijver, Marc J.
    Sukumar, Saraswati
    Chang, Howard Y.
    [J]. NATURE, 2010, 464 (7291) : 1071 - U148
12345