Topological journey of parasite-derived antigens for presentation by MHC class I molecules

被引:13
作者
Blanchard, Nicolas [1 ]
Shastri, Nilabh [1 ]
机构
[1] Univ Calif Berkeley, Div Immunol & Pathogenesis, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
基金
美国国家卫生研究院;
关键词
CD8(+) T-CELLS; CD8-ALPHA(+) DENDRITIC CELLS; CROSS-PRESENTATION; ENDOPLASMIC-RETICULUM; TOXOPLASMA-GONDII; CIRCUMSPOROZOITE PROTEIN; LISTERIA-MONOCYTOGENES; PARASITOPHOROUS VACUOLE; SOLUBLE-ANTIGENS; HOST-RESISTANCE;
D O I
10.1016/j.it.2010.08.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Within cells of their host, many bacteria and parasites inhabit specialized compartments, such as a modified phagosome for Mycobacterium tuberculosis or a parasitophorous vacuole for Toxoplasma gondii These locations could exclude microbial material from entry into the MHC class I surveillance pathway Remarkably, however, under these circumstances, cells can still signal the presence of invading pathogens to circulating CD8(+) T cells, which typically play a key role in protection against such intracellular organisms Here, we review MHC I presentation pathways in various contexts, ranging from model antigens in non-infectious settings to pathogen-infected cells We suggest that presentation of intracellular pathogens can be described as not just one but several distinct pathways, perhaps because diverse pathogens have evolved different strategies to interact with host cells
引用
收藏
页码:414 / 421
页数:8
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