共 89 条
Topological journey of parasite-derived antigens for presentation by MHC class I molecules
被引:13
作者:

Blanchard, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Div Immunol & Pathogenesis, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Div Immunol & Pathogenesis, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

Shastri, Nilabh
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h-index: 0
机构:
Univ Calif Berkeley, Div Immunol & Pathogenesis, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Div Immunol & Pathogenesis, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
机构:
[1] Univ Calif Berkeley, Div Immunol & Pathogenesis, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
基金:
美国国家卫生研究院;
关键词:
CD8(+) T-CELLS;
CD8-ALPHA(+) DENDRITIC CELLS;
CROSS-PRESENTATION;
ENDOPLASMIC-RETICULUM;
TOXOPLASMA-GONDII;
CIRCUMSPOROZOITE PROTEIN;
LISTERIA-MONOCYTOGENES;
PARASITOPHOROUS VACUOLE;
SOLUBLE-ANTIGENS;
HOST-RESISTANCE;
D O I:
10.1016/j.it.2010.08.004
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Within cells of their host, many bacteria and parasites inhabit specialized compartments, such as a modified phagosome for Mycobacterium tuberculosis or a parasitophorous vacuole for Toxoplasma gondii These locations could exclude microbial material from entry into the MHC class I surveillance pathway Remarkably, however, under these circumstances, cells can still signal the presence of invading pathogens to circulating CD8(+) T cells, which typically play a key role in protection against such intracellular organisms Here, we review MHC I presentation pathways in various contexts, ranging from model antigens in non-infectious settings to pathogen-infected cells We suggest that presentation of intracellular pathogens can be described as not just one but several distinct pathways, perhaps because diverse pathogens have evolved different strategies to interact with host cells
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收藏
页码:414 / 421
页数:8
相关论文
共 89 条
[61]
Cross-presentation: underlying mechanisms and role in immune surveillance
[J].
Rock, KL
;
Shen, L
.
IMMUNOLOGICAL REVIEWS,
2005, 207
:166-183

Rock, KL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

Shen, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA
[62]
Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
[J].
Rodriguez, A
;
Regnault, A
;
Kleijmeer, M
;
Ricciardi-Castagnoli, P
;
Amigorena, S
.
NATURE CELL BIOLOGY,
1999, 1 (06)
:362-368

Rodriguez, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France

Regnault, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France

Kleijmeer, M
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France

Ricciardi-Castagnoli, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France

Amigorena, S
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France Inst Curie, INSERM, U520, Sect Rech, F-75005 Paris, France
[63]
CLONED CYTO-TOXIC T-CELLS RECOGNIZE AN EPITOPE IN THE CIRCUMSPOROZOITE PROTEIN AND PROTECT AGAINST MALARIA
[J].
ROMERO, P
;
MARYANSKI, JL
;
CORRADIN, G
;
NUSSENZWEIG, RS
;
NUSSENZWEIG, V
;
ZAVALA, F
.
NATURE,
1989, 341 (6240)
:323-326

ROMERO, P
论文数: 0 引用数: 0
h-index: 0
机构: NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

MARYANSKI, JL
论文数: 0 引用数: 0
h-index: 0
机构: NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

CORRADIN, G
论文数: 0 引用数: 0
h-index: 0
机构: NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

NUSSENZWEIG, RS
论文数: 0 引用数: 0
h-index: 0
机构: NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

NUSSENZWEIG, V
论文数: 0 引用数: 0
h-index: 0
机构: NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

ZAVALA, F
论文数: 0 引用数: 0
h-index: 0
机构: NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA
[64]
Polymorphic secreted kinases are key virulence factors in toxoplasmosis
[J].
Saeij, J. P. J.
;
Boyle, J. P.
;
Coller, S.
;
Taylor, S.
;
Sibley, L. D.
;
Brooke-Powell, E. T.
;
Ajioka, J. W.
;
Boothroyd, J. C.
.
SCIENCE,
2006, 314 (5806)
:1780-1783

Saeij, J. P. J.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Boyle, J. P.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Coller, S.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Taylor, S.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Sibley, L. D.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Brooke-Powell, E. T.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Ajioka, J. W.
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

Boothroyd, J. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA
[65]
Mice deficient in LRG-47 display enhanced snsceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth
[J].
Santiago, HC
;
Feng, CG
;
Bafica, A
;
Roffe, E
;
Arantes, RM
;
Cheever, A
;
Taylor, G
;
Vierira, LQ
;
Aliberti, J
;
Gazzinelli, RT
;
Sher, A
.
JOURNAL OF IMMUNOLOGY,
2005, 175 (12)
:8165-8172

Santiago, HC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Feng, CG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Bafica, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Roffe, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Arantes, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Cheever, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

论文数: 引用数:
h-index:
机构:

Vierira, LQ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Aliberti, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Gazzinelli, RT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil
[66]
IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation
[J].
Saveanu, Loredana
;
Carroll, Oliver
;
Weimershaus, Mirjana
;
Guermonprez, Pierre
;
Firat, Elke
;
Lindo, Vivian
;
Greer, Fiona
;
Davoust, Jean
;
Kratzer, Roland
;
Keller, Susanna R.
;
Niedermann, Gabriele
;
van Endert, Peter
.
SCIENCE,
2009, 325 (5937)
:213-217

Saveanu, Loredana
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U580, F-75015 Paris, France
Univ Paris 05, Fac Med Rene Descartes, F-75015 Paris, France INSERM, U580, F-75015 Paris, France

Carroll, Oliver
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U580, F-75015 Paris, France
Univ Paris 05, Fac Med Rene Descartes, F-75015 Paris, France INSERM, U580, F-75015 Paris, France

Weimershaus, Mirjana
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U580, F-75015 Paris, France
Univ Paris 05, Fac Med Rene Descartes, F-75015 Paris, France INSERM, U580, F-75015 Paris, France

Guermonprez, Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U653, F-75006 Paris, France
Inst Curie, Ctr Rech, F-75006 Paris, France INSERM, U580, F-75015 Paris, France

Firat, Elke
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Clin Radiotherapy, D-79106 Freiburg, Germany INSERM, U580, F-75015 Paris, France

Lindo, Vivian
论文数: 0 引用数: 0
h-index: 0
机构:
M SCAN Ltd, Wokingham RG41 2TZ, Berks, England INSERM, U580, F-75015 Paris, France

Greer, Fiona
论文数: 0 引用数: 0
h-index: 0
机构:
M SCAN Ltd, Wokingham RG41 2TZ, Berks, England INSERM, U580, F-75015 Paris, France

论文数: 引用数:
h-index:
机构:

Kratzer, Roland
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U580, F-75015 Paris, France
Univ Paris 05, Fac Med Rene Descartes, F-75015 Paris, France INSERM, U580, F-75015 Paris, France

Keller, Susanna R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Internal Med, Div Endocrinol, Charlottesville, VA 22908 USA INSERM, U580, F-75015 Paris, France

Niedermann, Gabriele
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Clin Radiotherapy, D-79106 Freiburg, Germany INSERM, U580, F-75015 Paris, France

van Endert, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U580, F-75015 Paris, France
Univ Paris 05, Fac Med Rene Descartes, F-75015 Paris, France INSERM, U580, F-75015 Paris, France
[67]
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells
[J].
Savina, Ariel
;
Jancic, Carolina
;
Hugues, Stephanie
;
Guermonprez, Pierre
;
Vargas, Pablo
;
Moura, Ivan Cruz
;
Lennon-Dumenil, Ana-Maria
;
Seabra, Miguel C.
;
Raposo, Graca
;
Amigorena, Sebastian
.
CELL,
2006, 126 (01)
:205-218

Savina, Ariel
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Jancic, Carolina
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Hugues, Stephanie
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Guermonprez, Pierre
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Vargas, Pablo
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Moura, Ivan Cruz
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Lennon-Dumenil, Ana-Maria
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Seabra, Miguel C.
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Raposo, Graca
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France

Amigorena, Sebastian
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, INSERM, U653, F-75248 Paris 05, France
[68]
The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic Cells
[J].
Savina, Ariel
;
Peres, Audrey
;
Cebrian, Ignacio
;
Carmo, Nuno
;
Moita, Catarina
;
Hacohen, Nir
;
Moita, Luis F.
;
Amigorena, Sebastian
.
IMMUNITY,
2009, 30 (04)
:544-555

Savina, Ariel
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, INSERM U653, F-75248 Paris 05, France Inst Curie, INSERM U653, F-75248 Paris 05, France

Peres, Audrey
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, INSERM U653, F-75248 Paris 05, France Inst Curie, INSERM U653, F-75248 Paris 05, France

Cebrian, Ignacio
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, INSERM U653, F-75248 Paris 05, France Inst Curie, INSERM U653, F-75248 Paris 05, France

Carmo, Nuno
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Mol Med, Cell Biol Immune Syst Unit, P-1649028 Lisbon, Portugal Inst Curie, INSERM U653, F-75248 Paris 05, France

Moita, Catarina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Mol Med, Cell Biol Immune Syst Unit, P-1649028 Lisbon, Portugal Inst Curie, INSERM U653, F-75248 Paris 05, France

Hacohen, Nir
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA
Broad Inst Harvard, Cambridge, MA 02142 USA
MIT, Cambridge, MA USA Inst Curie, INSERM U653, F-75248 Paris 05, France

Moita, Luis F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Mol Med, Cell Biol Immune Syst Unit, P-1649028 Lisbon, Portugal Inst Curie, INSERM U653, F-75248 Paris 05, France

Amigorena, Sebastian
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Curie, INSERM U653, F-75248 Paris 05, France Inst Curie, INSERM U653, F-75248 Paris 05, France
[69]
Cross-presentation of cell-associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells
[J].
Schulz, O
;
Sousa, CRE
.
IMMUNOLOGY,
2002, 107 (02)
:183-189

Schulz, O
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK, London Res Inst, Immunobiol Lab, Lincolns Inn Fields Labs, London WC2A 3PX, England Canc Res UK, London Res Inst, Immunobiol Lab, Lincolns Inn Fields Labs, London WC2A 3PX, England

Sousa, CRE
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK, London Res Inst, Immunobiol Lab, Lincolns Inn Fields Labs, London WC2A 3PX, England Canc Res UK, London Res Inst, Immunobiol Lab, Lincolns Inn Fields Labs, London WC2A 3PX, England
[70]
THE PARASITOPHOROUS VACUOLE MEMBRANE SURROUNDING INTRACELLULAR TOXOPLASMA-GONDII FUNCTIONS AS A MOLECULAR-SIEVE
[J].
SCHWAB, JC
;
BECKERS, CJM
;
JOINER, KA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1994, 91 (02)
:509-513

SCHWAB, JC
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06510 YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06510

BECKERS, CJM
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06510 YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06510

JOINER, KA
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06510 YALE UNIV,SCH MED,DEPT INTERNAL MED,INFECT DIS SECT,NEW HAVEN,CT 06510