An improved protocol for the ruthenium(pybox)-catalyzed asymmetric alkene epoxidation

被引：35

作者：

Tse, MK ^{[1
]}

Bhor, S ^{[1
]}

Klawonn, M ^{[1
]}

Döbler, C ^{[1
]}

Beller, M ^{[1
]}

机构：

[1] Univ Rostock eV, Leibniz IfOK, D-18055 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 40期

关键词：

D O I：

10.1016/j.tetlet.2003.08.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A considerable rate enhancement in the ruthenium-catalyzed asymmetric epoxidation of olefins in the presence of PhI(OAc)(2) is reported. By the addition of H2O, the rate of the reaction was increased by two orders of magnitude. Reactions of both aliphatic and aromatic olefins were realized for the first time and enantioselectivities up to 71% ee were obtained. In addition an in situ generation of ruthenium pybox catalysts for faster screening of oxidation catalysts was also developed. (C) 2003 Published by Elsevier Ltd.

引用

页码：7479 / 7483

页数：5

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