Scaling Out by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): Multi-Gram Synthesis of Bromo- and Fluoro-benzofused Sultams Benzthiaoxazepine-1,1-dioxides

被引：50

作者：

Ullah, Farman ^{[3
]}

Samarakoon, Thiwanka ^{[1
,2
]}

Rolfe, Alan ^{[1
,2
]}

Kurtz, Ryan D. ^{[1
,2
]}

Hanson, Paul R. ^{[1
,2
]}

Organ, Michael G. ^{[3
]}

机构：

[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

[2] Univ Kansas KU CMLD, Ctr Chem Methodol & Lib Dev, Lawrence, KS 66047 USA

[3] York Univ, Dept Chem, N York, ON M3J 1P3, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 36期

关键词：

benzthiaoxazepine1,1-dioxides; flow chemistry; heterocycles; microwave chemistry; synthetic methods; DIVERSITY-ORIENTED SYNTHESIS; DOS APPROACH; THIN-FILMS; STRATEGY; HETEROCYCLES; CAPILLARIES; CHEMISTRY; GOLD;

D O I：

10.1002/chem.201001651

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented). Go with the flow! Using a combination of continuous-flow techniques and microwave irradiation, a 19-member collection of 5-10 gram quantities of benzthiaoxazepine-1,1-dioxides has been produced (see scheme). The elimination of intermediate- and largescale process optimization by invoking the concept of scale-out (rather than scale up) has significantly reduced the time necessary to prepare these compounds. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10959 / 10962

页数：4

共 36 条

[1] Diversity-oriented synthesis of privileged benzopyranyl heterocycles from s-cis-enones [J].