A copper-metalated, hybrid inorganic-organic polymer as an oxidative nuclease

被引：19

作者：

Chandrasekhar, V ^{[1
]}

Athimoolam, A ^{[1
]}

Krishnan, V ^{[1
]}

Azhakar, R ^{[1
]}

Madhavaiah, C ^{[1
]}

Verma, S ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2005年 / 08期

关键词：

chemical nucleases; phosphazenes; pendant polymers; copper complexes; phosphate ester hydrolysis; heterogeneous catalysis;

D O I：

10.1002/ejic.200400727

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This study describes nucleolytic activity of a copper-metalated, multisite-coordinating, hybrid polymer CPPL-Cu under oxidative conditions. Rapid relaxation of supercoiled plasmid DNA was observed and mechanistic probing by chemical and enzymatic assays revealed involvement of single-oxygen-derived reactive species. The heterogeneous nature of the catalyst allowed a facile recycling of the artificial nuclease. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).

引用

页码：1482 / 1486

页数：5

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