A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells

被引：7

作者：

Kawamura, Akira ^{[1
]}

Iacovidou, Maria ^{[1
]}

Takaoka, Anna ^{[1
]}

Soll, Clifford E. ^{[1
]}

Blumenstein, Michael ^{[1
]}

机构：

[1] CUNY Hunter Coll, Dept Chem, New York, NY 10065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期

关键词：

dang gui shao yao San; coagulation; HUVEC; TDEYA; genomic screening; SerpinB2; COX2; perlecan; TI-PARP; oligonucleotide array;

D O I：

10.1016/j.bmcl.2007.10.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

From Toki-shakuyaku-san, an herbal formulation for 'cleansing stagnated blood,' a key gene regulatory compound was purified and identified through a screening based on DNA microarray and real-time PCR. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6879 / 6882

页数：4

共 22 条

[1] Significance of the plasminogen activator inhibitor of placental type (PAI-2) in pregnancy [J].

Åstedt, B ;

Lindoff, C ;

Lecander, I .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1998, 24 (05) :431-435

[2]

Coldren CD, 2003, PLANTA MED, V69, P725, DOI 10.1055/s-2003-42791

[3] FIBRINOLYTIC PARAMETERS IN NORMOTENSIVE PREGNANCY WITH INTRAUTERINE FETAL GROWTH-RETARDATION AND IN SEVERE PREECLAMPSIA [J].

ESTELLES, A ;

GILABERT, J ;

ESPANA, F ;

AZNAR, J ;

GALBIS, M .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 165 (01) :138-142

[4] EVALUATION OF PLASMINOGEN ACTIVATORS AND PLASMINOGEN-ACTIVATOR INHIBITORS IN PLASMA AND AMNIOTIC-FLUID IN PREGNANCIES COMPLICATED WITH INTRAUTERINE FETAL GROWTH-RETARDATION [J].

GILABERT, J ;

ESTELLES, A ;

AYUSO, MJ ;

ESPANA, F ;

CHIRIVELLA, M ;

GRANCHA, S ;

MICO, JM ;

AZNAR, J .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1994, 38 (03) :157-162

[5]

Grancha S, 1996, THROMB HAEMOSTASIS, V76, P761

[6] COX-2: Friend or foe? [J].

Iezzi, Annalisa ;

Ferri, Claudio ;

Mezzetti, Andrea ;

Cipollone, Francesco .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (16) :1715-1721

[7] Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray [J].

Iizuka, N ;

Oka, M ;

Yamamoto, K ;

Taruoku, A ;

Miyamoto, K ;

Miyamoto, T ;

Uchimura, S ;

Hamamoto, Y ;

Okita, K .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (04) :666-672

[8]

Kano T, 1991, JPN J FERTIL STERIL, V36, P612

[9]

KANO Y, 1989, CHEM PHARM BULL, V37, P193

[10] Rediscovery of natural products using genomic tools [J].

Kawamura, A ;

Brekman, A ;

Grigoryev, Y ;

Hasson, TH ;

Takaoka, A ;

Wolfe, S ;

Soll, CE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (11) :2846-2849

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