B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL

被引：13

作者：

Fang, Hong ^{[1
]}

Wang, Wei ^{[1
]}

El Hussein, Siba ^{[1
]}

Morita, Kiyomi ^{[2
]}

Beird, Hannah C. ^{[3
]}

Mitra, Akash ^{[3
,4
]}

Loghavi, Sanam ^{[1
]}

Lin, Pei ^{[1
]}

Jabbour, Elias J. ^{[2
]}

Khoury, Joseph D. ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Hematopathol, MS 072,1515 Holcombe Blvd, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Genom Med, Houston, TX USA

[4] Grad Sch Biomed Sci, Quantitat Sci Grad Training Program, Houston, TX USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 194卷 / 06期

关键词：

BCL11B; early T-cell precursor lymphoblastic leukaemia; T-lymphoblastic leukaemia; lymphoma; immunohistochemistry; T-cell differentiation; DIFFERENTIATION; PROLIFERATION; CHECKPOINT; APOPTOSIS;

D O I：

10.1111/bjh.17681

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

B-cell lymphoma/leukaemia 11B (BCL11B) is an essential transcription factor for T-cell lineage commitment and maturation. We investigated BCL11B expression by immunohistochemistry in T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL) (n = 115). The majority (83%) of early T-cell precursor T-ALL/LBL (ETP-ALL) cases showed negative BCL11B expression, while most (84%) of non-ETP-ALL/LBL were positive for BCL11B. A simplified three-marker [BCL11B, cluster of differentiation 5 (CD5), CD13] immunophenotypic score discriminated reliably between ETP-ALL and non-ETP-ALL/LBL. In ETP-ALL, patients with positive BCL11B expression had a better overall survival than those with negative BCL11B (P = 0 center dot 009). In summary, BCL11B is a valuable marker for T-ALL/LBL subtyping and serves as a potential prognostic marker in patients with ETP-ALL.

引用

页码：1034 / 1038

页数：5

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