Association between Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

被引:23
作者
Chen, Hui [1 ]
Nie, Shuping [1 ]
Lu, Ming [1 ,2 ]
机构
[1] Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Jinan 250012, Peoples R China
[2] Shandong Univ, Qilu Hosp, Clin Epidemiol Unit, Jinan 250012, Peoples R China
关键词
Gene polymorphism; meta-analysis; plasminogen activator inhibitor-1; recurrent spontaneous abortion; COAGULATION-FACTOR-XIII; 4G/5G POLYMORPHISM; PAI-1; GENES; IMPAIRED FIBRINOLYSIS; MISCARRIAGE; MUTATIONS; WOMEN; ACE; THROMBOPHILIA; INVASION;
D O I
10.1111/aji.12321
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human plasminogen activator inhibitor-1 (PAI-1) is closely related to embryonic development and pregnancy success. The association between PAI-1 gene polymorphisms (PAI-1-844G/A and PAI-1-675G/A) and the risk of recurrent pregnancy loss (RPL) is controversial. Therefore, we perform this review to clarify the association between PAI-1 gene polymorphisms and RPL risk. We performed a systematic search for studies that described the effect of PAI-1 polymorphisms on RPL risk. The odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were considered under recessive genetic models. Furthermore, we conducted a subgroup analysis based on the studies' geographic regions of origin. Data were analyzed using Stata 11.2 software. Eighteen studies were included, and a high degree of statistical heterogeneity existed among the studies. In this study, we found a significant association between the PAI-1-675G/A polymorphism and the risk of RPL under the recessive model (OR=1.70, 95% CI=1.21-2.38). However, no significant association between the PAI-1-844G/A polymorphism and RPL was noted. PAI-1-675G/A (4G/5G) polymorphisms play a potential role in RPL. The screening of PAI-1 (4G/5G) gene mutations should be included during an RPL diagnostic workup, and patients should be treated using anticoagulant therapy during pregnancy if necessary.
引用
收藏
页码:292 / 300
页数:9
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