共 39 条
Association between Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis
被引:23
作者:
Chen, Hui
[1
]
Nie, Shuping
[1
]
Lu, Ming
[1
,2
]
机构:
[1] Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Jinan 250012, Peoples R China
[2] Shandong Univ, Qilu Hosp, Clin Epidemiol Unit, Jinan 250012, Peoples R China
关键词:
Gene polymorphism;
meta-analysis;
plasminogen activator inhibitor-1;
recurrent spontaneous abortion;
COAGULATION-FACTOR-XIII;
4G/5G POLYMORPHISM;
PAI-1;
GENES;
IMPAIRED FIBRINOLYSIS;
MISCARRIAGE;
MUTATIONS;
WOMEN;
ACE;
THROMBOPHILIA;
INVASION;
D O I:
10.1111/aji.12321
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Human plasminogen activator inhibitor-1 (PAI-1) is closely related to embryonic development and pregnancy success. The association between PAI-1 gene polymorphisms (PAI-1-844G/A and PAI-1-675G/A) and the risk of recurrent pregnancy loss (RPL) is controversial. Therefore, we perform this review to clarify the association between PAI-1 gene polymorphisms and RPL risk. We performed a systematic search for studies that described the effect of PAI-1 polymorphisms on RPL risk. The odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were considered under recessive genetic models. Furthermore, we conducted a subgroup analysis based on the studies' geographic regions of origin. Data were analyzed using Stata 11.2 software. Eighteen studies were included, and a high degree of statistical heterogeneity existed among the studies. In this study, we found a significant association between the PAI-1-675G/A polymorphism and the risk of RPL under the recessive model (OR=1.70, 95% CI=1.21-2.38). However, no significant association between the PAI-1-844G/A polymorphism and RPL was noted. PAI-1-675G/A (4G/5G) polymorphisms play a potential role in RPL. The screening of PAI-1 (4G/5G) gene mutations should be included during an RPL diagnostic workup, and patients should be treated using anticoagulant therapy during pregnancy if necessary.
引用
收藏
页码:292 / 300
页数:9
相关论文