Large pore mesoporous silica nanomaterials for application in delivery of biomolecules

被引：199

作者：

Knezevic, Nikola Z. ^{[1
,2
]}

Durand, Jean-Olivier ^{[2
]}

机构：

[1] European Univ, Fac Pharm, Novi Sad 21000, Serbia

[2] UMR 5253 CNRS UM2 ENSCM UM1, Inst Charles Gerhardt Montpellier, Equipe Chim Mol & Org Solide CC1701, F-34095 Montpellier 05, France

来源：

NANOSCALE | 2015年 / 7卷 / 06期

关键词：

CONTROLLED-RELEASE; FACILE SYNTHESIS; NANOPARTICLES; SIZE; BIODISTRIBUTION; ADSORPTION; COPOLYMER; TRIBLOCK; IMMOBILIZATION; NANOSPHERES;

D O I：

10.1039/c4nr06114d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Various approaches for the synthesis of mesoporous silicate nanoparticles (MSN) with large pore (LP) diameters (in the range of 3-50 nm) are reviewed in this article. The work also covers the construction of magnetic analogues of large pore-mesoporous silica nanoparticles (LPMMSN) and their biomedical applications. The constructed materials exhibit vast potential for application in the loading and delivery of large drug molecules and biomolecules. Literature reports on the application of LPMSN and LPMMSN materials for the adsorption and delivery of proteins, enzymes, antibodies, and nucleic acids are covered in depth, which exemplify their highly potent characteristics for use in drug and biomolecule delivery to diseased tissues.

引用

页码：2199 / 2209

页数：11

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