The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity

被引:20
|
作者
Czogala, Wojciech [1 ]
Strojny, Wojciech [1 ]
Tomasik, Przemyslaw [2 ]
Multanowski, Miroslaw Bik [3 ]
Wojcik, Malgorzata [4 ]
Miklusiak, Klaudia [5 ]
Krzysztofik, Emil [5 ]
Wrobel, Albert [5 ]
Miklusiak, Karol [5 ]
Skoczen, Szymon [1 ,6 ]
机构
[1] Univ Childrens Hosp Krakow, Dept Pediat Oncol & Hematol, PL-30663 Krakow, Poland
[2] Jagiellonian Univ Med Coll, Fac Med, Dept Clin Biochem, PL-30663 Krakow, Poland
[3] Jagiellonian Univ Med Coll, Fac Med, Dept Med Genet, PL-30663 Krakow, Poland
[4] Jagiellonian Univ Med Coll, Fac Med, Dept Pediat & Adolescent Endocrinol, PL-30663 Krakow, Poland
[5] Jagiellonian Univ Med Coll, Student Sci Grp Pediat Oncol & Hematol, PL-30663 Krakow, Poland
[6] Jagiellonian Univ Med Coll, Fac Med, Dept Pediat Oncol & Hematol, PL-30663 Krakow, Poland
关键词
IGF; IGFBP; obesity; children; microarray; MESSENGER-RNA EXPRESSION; BODY-MASS INDEX; I IGF-I; SERUM-LEVELS; BLOOD-PRESSURE; FACTOR (IGF)-I; GHRELIN LEVELS; SMOOTH-MUSCLE; CHILDREN; ADOLESCENTS;
D O I
10.3390/nu13072432
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation.
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页数:18
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