Is ApoE gene a risk factor for vascular dementia in Han Chinese?

被引：0

作者：

Yang, JD

Feng, GY

Zhang, J

Hui, Z

Breen, G

Clair, DS

He, L ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China

[2] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

[3] Univ Aberdeen, Dept Mental Hlth, Sch Med, Aberdeen AB25 2ZD, Scotland

[4] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2001年 / 7卷 / 02期

关键词：

vascular dementia; Alzheimer's disease; apolipoprotein E; Han Chinese population;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have compared the apolipoprotein E (ApoE) genotypes of Han Chinese with late-onset sporadic Alzheimer's disease (LOAD, n=191), and vascular dementia (VaD, n=124) to controls (n=218) with a similar age distribution. The frequency of ApoE epsilon4 allele in the LOAD group was significantly higher than that in the control group (30.1% versus 10.55%, p<10(-7)). The risk rate of LOAD was 3.5 times higher for carriers with at least one ApoE <epsilon>4 allele than for non-epsilon4 bearing controls. ApoE epsilon4 allele was also significantly associated with vascular dementia (OR=1.75, p=0.026). Our findings support previous reports of a positive association between ApoE epsilon4 and both Alzheimer's disease and vascular dementia in Han Chinese.

引用

页码：217 / 219

页数：3

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