Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems

被引：16

作者：

Zhao, Qian ^{[1
]}

Han, Bo ^{[2
]}

Wang, Biao ^{[1
]}

Leng, Hai-Jun ^{[2
]}

Peng, Cheng ^{[1
,2
]}

Huang, Wei ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Minist Educ, Key Lab Standardizat Chinese Med, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 34期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC-SYNTHESIS; ALPHA; BETA-UNSATURATED ALDEHYDES; ACYL AZOLIUMS; MICHAEL ADDITION; ENANTIOSELECTIVE SYNTHESIS; TANDEM REACTIONS; MODIFIED ENALS; NHC CATALYSIS; ANNULATION; ACTIVATION;

D O I：

10.1039/c5ra01254f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two consecutive N-heterocyclic carbene (NHC) catalytic systems were combined in a one-pot cascade reaction for the assembly of aromatic aldehydes and 2-haloenals into a structurally complex gamma-lactone backbone. To our knowledge, this is the first report of NHC-catalyzed [3 + 2] annulation of alpha,beta-unsaturated acylazoliums with 1,2-bisnucleophiles.

引用

页码：26972 / 26976

页数：5

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