Roles of endothelial dysfunction in coronary artery disease

被引：38
|
作者：
Forgione, MA [1 ]
Leopold, JA [1 ]
Loscalzo, J [1 ]
机构：
[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Dept Med, Boston, MA 02118 USA
来源：
CURRENT OPINION IN CARDIOLOGY | 2000年 / 15卷 / 06期
关键词：
D O I：
10.1097/00001573-200011000-00007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Endothelial dysfunction is an early and persistent vascular abnormality in the evolution of atherothrombotic disease. Risk factors for atherosclerosis promote an inflammatory oxidative environment in the vasculature that induces pathologic changes in endothelial function, including the support of enhanced smooth muscle tone, thrombosis, and smooth muscle proliferation, This article provides an overview of the molecular basis of endothelial dysfunction and of its diagnosis and treatment. (C) Lippincott Williams & Wilkins, Inc.
引用
收藏
页码：409 / 415
页数：7
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