Discrepancy of subjective and objective sleep problems in Alzheimer's disease and mild cognitive impairment detected by a home-based sleep analysis

被引：14
作者：
Tadokoro, Koh [1 ]
Ohta, Yasuyuki [1 ]
Hishikawa, Nozomi [1 ]
Nomura, Emi [1 ,2 ]
Wakutani, Yosuke [2 ]
Takao, Yoshiki [2 ]
Omote, Yoshio [1 ]
Takemoto, Mami [1 ]
Yamashita, Toru [1 ]
Abe, Koji [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan
[2] KurashikiHeisei Hosp, Dept Neurol, 4-3-38 Oimatsu Cho, Kurashiki, Okayama 7100826, Japan
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2020年 / 74卷
关键词：
Alzheimer's disease; Mild cognitive impairment; Sleep; WatchPAT; QUALITY INDEX; ALGORITHM; INSOMNIA; DECLINE; NEURONS; SYSTEM; BRAIN;
D O I：
10.1016/j.jocn.2020.01.085
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
There is a strong relationship between Alzheimer's disease (AD) and sleep problems, and a sleep condition is informative for evaluating the AD status. In the present study, we evaluated subjective sleep problems in AD and mild cognitive impairment (MCI) with self-check questionnaires and objective sleep problems with a convenient home-based portable device, WatchPAT. A total of 63 subjects with normal cognition (NC) (n = 22), MCI (n = 20), and AD (n = 21) were cross-sectionally investigated. AD patients showed a better self-check Pittsburgh sleep quality index (PSQI) score (*p < 0.05) than NC and MCI patients. On the other hand, WatchPAT analysis showed a significantly reduced rapid eye movement (REM) sleep (*p < 0.05) and increased light sleep in AD patients (*p < 0.05) compared with NC subjects, and mildly reduced REM and increased light sleep in MCI subjects. The present study revealed a gap between the subjective self-check sleep questions and the objective WatchPAT analysis in AD patients. Thus, a home-based sleep study with WatchPAT is a useful tool to detect an objective sleep problem in AD and the risk of MCI conversion into AD. (C) 2020 Elsevier Ltd. All rights reserved.
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收藏
页码：76 / 80
页数：5
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