Deep eutectic solvent: a simple, environmentally benign reaction media for regioselective synthesis of 2,3,4-trisubstituted 1H-pyrroles

被引：29

作者：

Kalmode, Hanuman P. ^{[1
]}

Vadagaonkar, Kamlesh S. ^{[1
]}

Murugan, Kaliyappan ^{[2
]}

Prakash, Sattey ^{[3
]}

Chaskar, Atul C. ^{[1
,3
]}

机构：

[1] Inst Chem Technol, Dept Dyestuff Technol, Bombay 400019, Maharashtra, India

[2] Natl Taiwan Univ, Taipei 10617, Taiwan

[3] Univ Mumbai, Natl Ctr Nanosci & Nanotechnol, Bombay 400098, Maharashtra, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 44期

关键词：

ONE-POT SYNTHESIS; HIGHLY EFFICIENT SYNTHESIS; IONIC LIQUIDS; POLYSUBSTITUTED PYRROLES; FUNCTIONALIZED PYRROLES; 1,3-DICARBONYL COMPOUNDS; BIOLOGICAL EVALUATION; 3-COMPONENT SYNTHESIS; SUBSTITUTED PYRROLES; SOLID CATALYST;

D O I：

10.1039/c5ra03270a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Choline hydroxide has been successfully employed as an efficient base as well as reaction media for the synthesis of 2,3,4-trisubstituted 1H-pyrroles from methyl 2-isocyanoacetate and alpha,beta-unsaturated ketones. The choline hydroxide used is inexpensive, non-toxic, recyclable and environmentally friendly. Mild reaction conditions and an easy workup procedure are the striking features of this protocol. This transformation proceeds through the 1,4-conjugate addition of methyl 2-isocyanoacetate with alpha,beta-unsaturated ketones followed by intramolecular cyclization-oxidation reaction.

引用

页码：35166 / 35174

页数：9

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