FOX and ETS family transcription factors regulate the pigment cell lineage in planarians

被引：27
作者：
He, Xinwen [1 ,2 ]
Lindsay-Mosher, Nicole [1 ,2 ]
Li, Yan [1 ,3 ]
Molinaro, Alyssa M. [1 ,2 ]
Pellettieri, Jason [4 ]
Pearson, Bret J. [1 ,2 ,3 ]
机构：
[1] Hosp Sick Children, Program Dev & Stem Cell Biol, Toronto, ON M5G 0A4, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5G 0A4, Canada
[3] Ontario Inst Canc Res, Toronto, ON M5G 0A4, Canada
[4] Keene State Coll, Dept Biol, Keene, NH 03435 USA
来源：
DEVELOPMENT | 2017年 / 144卷 / 24期
基金：
美国国家卫生研究院; 加拿大自然科学与工程研究理事会; 美国国家科学基金会; 加拿大健康研究院;
关键词：
Planarian; Pigment cell; Schmidtea mediterranea; Regeneration; SCHMIDTEA-MEDITERRANEA; STEM-CELLS; NEURAL CREST; REGENERATION; MELANOCYTES; EXPRESSION; SYSTEM; SKIN; PROLIFERATION; SPECIFICATION;
D O I：
10.1242/dev.156349
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Many pigment cells acquire unique structural properties and gene expression profiles during animal development. The underlying differentiation pathways have been well characterized in cells formed during embryogenesis, such as the neural crest-derived melanocyte. However, much less is known about the developmental origins of pigment cells produced in adult organisms during tissue homeostasis and repair. Here we report a lineage analysis of ommochrome-and porphyrin-producing cells in the brown, freshwater planarian Schmidtea mediterranea. Using an RNA-sequencing approach, we identified two classes of markers expressed in sequential fashion when new pigment cells are generated during regeneration or in response to pigment cell ablation. We also report roles for FOXF-1 and ETS-1 transcription factors, as well as for an FGFR-like molecule, in the specification and maintenance of this cell type. Together, our results provide insights into mechanisms of adult pigment cell development in the strikingly colorful Platyhelminthes phylum.
引用
收藏
页码：4540 / 4551
页数：12
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