Small Ubiquitin-Like Modifier 4 (SUMO4) gene M55V Polymorphism and Type 2 Diabetes Mellitus: a Meta-analysis including 6,823 subjects

被引:30
作者
Li, Yan-yan [1 ,2 ]
Wang, Hui [3 ]
Yang, Xin-xing [1 ]
Geng, Hong-yu [1 ]
Gong, Ge [1 ,4 ]
Kim, Hyun Jun [5 ]
Zhou, Yan-hong [1 ]
Wu, Jing-jing [6 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gerontol, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Inst Clin Med, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Gen Hosp, Dept Gerontol, Nanjing, Jiangsu, Peoples R China
[5] Univ Cincinnati, Dept Physiol, Cincinnati, OH USA
[6] Nanjing Med Univ, Affiliated Hosp 1, Dept Nephrol, Nanjing, Jiangsu, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2017年 / 8卷
基金
中国国家自然科学基金;
关键词
small ubiquitin-like modifier 4; rs237025; polymorphism; type 2 diabetes mellitus; meta-analysis; NF-KAPPA-B; INSULIN-RESISTANCE; MET55VAL POLYMORPHISM; ENDOTHELIAL-CELLS; CHROMOSOME; 6Q; IKK-BETA; SUSCEPTIBILITY; ASSOCIATION; GLUCOSE; VARIANT;
D O I
10.3389/fendo.2017.00303
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Many studies suggest that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter. Objective and methods: A meta-analysis consisting of 6,823 subjects from 10 studies was conducted to elucidate relationship between the SUMO4 M55V gene polymorphism and T2DM. Depending on the heterogeneity of the data, either a fixed or random-effects model would be used to assess the combined odds ratio (ORs) and their corresponding 95% confidence interval (CI). Results: SUMO4 gene M55V polymorphism was significantly associated with T2DM in the whole population under allelic (OR: 1.18, 95% CI: 1.10-1.28, P = 1.63 x 10(-5)), recessive (OR: 1.59, 95% CI: 1.14-2.23, P = 0.006), dominant (OR: 0.815, 95% CI: 0.737-0.901, P = 6.89 x 10(-5)), homozygous (OR: 1.415, 95% CI: 1.170-1.710, P = 0.0003), heterozygous (OR: 1.191, 95% CI: 1.072-1.323, P = 0.001), and additive genetic models (OR: 1.184, 95% CI: 1.097-1.279, P = 1.63 x 10(-5)). In our subgroup analysis, a significant association was found again in the Chinese population, but not in Japanese or Iranian population. Conclusion: SUMO4 gene M55V polymorphism may correlate with increased T2DM risk. Chinese carriers of the V allele of the SUMO4 gene M55V polymorphism may be predisposed to developing T2DM.
引用
收藏
页数:11
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