Cardiovascular Aging and Physical Activity: Insights From Metabolomics

被引：6
作者：
Lim, Ryan Mao Heng [1 ]
Koh, Angela S. S. [1 ,2 ]
机构：
[1] Natl Heart Ctr Singapore, Singapore, Singapore
[2] Duke Nat Univ Singapore Sch Med, Singapore, Singapore
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
基金：
英国医学研究理事会;
关键词：
aging; cardiovascular disease; metabolomics; physical activity; cardiovascular trial; musculoskeletal function; HEART-FAILURE; SKELETAL-MUSCLE; OLDER-ADULTS; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; BLOOD-PRESSURE; EXERCISE; RISK; METAANALYSIS; MECHANISMS;
D O I：
10.3389/fcvm.2021.728228
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The purpose of this review is to explore how metabolomics can help uncover mechanisms through which physical activity may influence the progression of cardiovascular aging. Cardiovascular aging is a process of functional and structural changes in older adults which can progress to cardiovascular disease. Metabolomics profiling is an investigative tool that can track the diverse changes which occur in human biochemistry with physical activity and aging. This mini review will summarize published investigations in metabolomics and physical activity, with a specific focus on the metabolic pathways that connect physical activity with cardiovascular aging.
引用
收藏
页数：7
相关论文
共 65 条
[11]   THE EFFECT OF INSULIN ON THE DISPOSAL OF INTRAVENOUS GLUCOSE - RESULTS FROM INDIRECT CALORIMETRY AND HEPATIC AND FEMORAL VENOUS CATHETERIZATION [J].
DEFRONZO, RA ;
JACOT, E ;
JEQUIER, E ;
MAEDER, E ;
WAHREN, J ;
FELBER, JP .
DIABETES, 1981, 30 (12) :1000-1007
[12]   Natriuretic peptides enhance the oxidative capacity of human skeletal muscle [J].
Engeli, Stefan ;
Birkenfeld, Andreas L. ;
Badin, Pierre-Marie ;
Bourlier, Virginie ;
Louche, Katie ;
Viguerie, Nathalie ;
Thalamas, Claire ;
Montastier, Emilie ;
Larrouy, Dominique ;
Harant, Isabelle ;
de Glisezinski, Isabelle ;
Lieske, Stefanie ;
Reinke, Julia ;
Beckmann, Bibiana ;
Langin, Dominique ;
Jordan, Jens ;
Moro, Cedric .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (12) :4675-4679
[13]   Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors [J].
Fiuza-Luces, Carmen ;
Santos-Lozano, Alejandro ;
Joyner, Michael ;
Carrera-Bastos, Pedro ;
Picazo, Oscar ;
Zugaza, Jose L. ;
Izquierdo, Mikel ;
Ruilope, Luis M. ;
Lucia, Alejandro .
NATURE REVIEWS CARDIOLOGY, 2018, 15 (12) :731-743
[14]   Exercise Therapy for Older Heart Failure Patients [J].
Fleg, Jerome L. .
HEART FAILURE CLINICS, 2017, 13 (03) :607-+
[15]  
Gao F, 2021, AGING-US, V13, P14785, DOI 10.18632/aging.203144
[16]   Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth [J].
Gibb, Andrew A. ;
Epstein, Paul N. ;
Uchida, Shizuka ;
Zheng, Yuting ;
McNally, Lindsey A. ;
Obal, Detlef ;
Katragadda, Kartik ;
Trainor, Patrick ;
Conklin, Daniel J. ;
Brittian, Kenneth R. ;
Tseng, Michael T. ;
Wang, Jianxun ;
Jones, Steven P. ;
Bhatnagar, Aruni ;
Hill, Bradford G. .
CIRCULATION, 2017, 136 (22) :2144-2157
[17]   Metabolic Flexibility in Health and Disease [J].
Goodpaster, Bret H. ;
Sparks, Lauren M. .
CELL METABOLISM, 2017, 25 (05) :1027-1036
[18]   Regulation of energy metabolism of the heart during acute increase in heart work [J].
Goodwin, GW ;
Taylor, CS ;
Taegtmeyer, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) :29530-29539
[19]   Exercise and cardiovascular risk reduction: Time to update the rationale for exercise? [J].
Green, Daniel J. ;
O'Driscoll, Gerry ;
Joyner, Michael J. ;
Cable, Nigel T. .
JOURNAL OF APPLIED PHYSIOLOGY, 2008, 105 (02) :766-768
[20]   Exercise training and blood lipids in hyperlipidemic and normolipidemic adults: A meta-analysis of randomized, controlled trials [J].
Halbert, JA ;
Silagy, CA ;
Finucane, P ;
Withers, RT ;
Hamdorf, PA .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 1999, 53 (07) :514-522
1234567