Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA

被引：121

作者：

Limmon, Gino V. ^{[1
]}

Arredouani, Mohamed ^{[2
]}

McCann, Kelly L. ^{[1
]}

Minor, Radiah A. Corn ^{[1
]}

Kobzik, Lester ^{[2
]}

Imani, Farhad ^{[1
]}

机构：

[1] NIEHS, NIH, Lab Resp Biol, Durham, NC 27709 USA

[2] Harvard Univ, Dept Environm Hlth, Cambridge, MA 02138 USA

来源：

FASEB JOURNAL | 2008年 / 22卷 / 01期

关键词：

lung; epithelium; inflammation; virus infection;

D O I：

10.1096/fj.07-8348com

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-stranded RNA (dsRNA) is a potent signal to the host immune system for the presence of an ongoing viral infection. The presence of dsRNA, intracellularly or extracellularly, leads to the induction of innate inflammatory cytokines in many cell types including epithelial cells. However, the cell surface receptor for recognition of extracellular dsRNA is not yet determined. Here, we report that extracellular dsRNA is recognized and internalized by scavenger receptor class-A (SR-A). Treatment of human epithelial cells with specific antagonists of SR-A or with an anti-SR-A antibody significantly inhibited dsRNA induction of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, and regulated on activation normal T-cell expressed and secreted (RANTES). Furthermore, intranasal dsRNA treatment of SR-A-deficient (SR-A(-/-)) mice showed a significant decrease in the expression of inflammatory cytokines and a corresponding decrease in the accumulation of polymorphonuclear leukocytes (PMNs) in lungs. These data provide direct evidence that SR-A is a novel cell surface receptor for dsRNA, and therefore, SR-A may play a role in antiviral immune responses.-Limmon, G. V., Arredouani, M., McCann, K. L., Corn Minor, R. A., Kobzik, L., Imani, L. Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA.

引用

页码：159 / 167

页数：9

共 45 条

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