Platelet Parameters in First-Episode Patients with Schizophrenia and Bipolar Disorder

被引:2
作者
Almis, Behice Han [1 ]
Egilmez, Oguzhan Bekir [1 ]
机构
[1] Adiyaman Univ, Sch Med, Dept Psychiat, Adiyaman, Turkey
关键词
Bipolar disorder; mean platelet volume; platelet parameters; plateletcrit; schizophrenia; MENTAL-DISORDERS; VOLUME; DEPRESSION; SIZE; RISK; MPV;
D O I
10.5152/pcp.2021.21695
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Measurement of platelet parameters, especially mean platelet volume (MPV), in mental disorders has been gaining importance. MPV is an indicator of platelet activity, and increased MPV is considered a risk factor for cardiovascular disease. Cardiovascular diseases and associated mortality are more common in patients with schizophrenia (SZ) and bipolar disorder (BD) than in the general population. We aimed to evaluate platelet parameters, including MPV, platelet count (PLT), platelet distribution volume (PDW), and plateletcrit (PCT) level, in first-episode patients with SZ and BD before disease progression and the effect of antipsychotic drugs caused changes in their lives. Methods: In this retrospective cohort study, we compared the platelet parameters in 72 patients with SZ at the time of their first psychotic episode and 63 patients with BD at the time of their first manic episode with 64 healthy controls. Results: SZ group had significantly lower MPV and PCT values than the control group (P = .003 and P = .03, respectively). BD group had significantly lower MPV and PCT values than the control group (P = .001 and P = .02, respectively). Conclusion: This is the first study to compare the platelet parameters between first-episode patients with SZ and BD and healthy controls. Although a few studies have reported an increase or decrease in platelet parameters in SZ and BD, our results are valuable in terms of evaluating platelet parameters in first-episode patients who have not started drugs.
引用
收藏
页码:339 / 343
页数:5
相关论文
共 27 条
  • [1] C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia
    Balcioglu, Yasin Hasan
    Kirlioglu, Simge Seren
    [J]. PSYCHIATRY INVESTIGATION, 2020, 17 (09) : 902 - 910
  • [2] Platelet size: Measurement, physiology and vascular disease
    Bath, PMW
    Butterworth, RJ
    [J]. BLOOD COAGULATION & FIBRINOLYSIS, 1996, 7 (02) : 157 - 161
  • [3] PLATELET SIZE IN MYOCARDIAL-INFARCTION
    CAMERON, HA
    PHILLIPS, R
    IBBOTSON, RM
    CARSON, PHM
    [J]. BRITISH MEDICAL JOURNAL, 1983, 287 (6390) : 449 - 451
  • [4] Association of mean Platelet volume with DSM-IV major depression in a large community-based population: The MELEN study
    Canan, Fatih
    Dikici, Suber
    Kutlucan, Ali
    Celbek, Gokhan
    Coskun, Hulya
    Gungor, Adem
    Aydin, Yusuf
    Kocaman, Gulsen
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 2012, 46 (03) : 298 - 302
  • [5] Use of general medical services by VA patients with psychiatric disorders
    Cradock-O'Leary, J
    Young, AS
    Yano, EM
    Wang, MM
    Lee, ML
    [J]. PSYCHIATRIC SERVICES, 2002, 53 (07) : 874 - 878
  • [6] Mental disorders and quality of diabetes care in the veterans health administration
    Desai, MM
    Rosenheck, RA
    Druss, BG
    Perlin, JB
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (09) : 1584 - 1590
  • [7] Mental disorders and use of cardiovascular procedures after myocardial infarction
    Druss, BG
    Bradford, DW
    Rosenheck, RA
    Radford, MJ
    Krumholz, HM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (04): : 506 - 511
  • [8] CHARACTERIZATION OF [H-3]-LABELED LYSERGIC-ACID DIETHYLAMIDE BINDING TO A 5-HYDROXYTRYPTAMINE RECEPTOR ON HUMAN-PLATELET MEMBRANES
    GEANEY, DP
    SCHACHTER, M
    ELLIOT, JM
    GRAHAMESMITH, DG
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) : 87 - 93
  • [9] Cardiovascular effects of psychotic illnesses and antipsychotic therapy
    Howell, Sandra
    Yarovova, Ekaterina
    Khwanda, Ahmad
    Rosen, Stuart D.
    [J]. HEART, 2019, 105 (24) : 1852 - 1859
  • [10] Neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and mean platelet volume as systemic inflammatory markers in different states of bipolar disorder
    Inanli, Ikbal
    Aydin, Memduha
    Caliskan, Ali Metehan
    Eren, Ibrahim
    [J]. NORDIC JOURNAL OF PSYCHIATRY, 2019, 73 (06) : 372 - 379