Lifetime-Based Responsive Probes: Design and Applications in Biological Analysis

被引：3

作者：

Jia, Hui ^{[1
]}

Liu, Yiheng ^{[1
]}

Hu, Jing-Jing ^{[1
]}

Li, Guogang ^{[1
]}

Lou, Xiaoding ^{[1
]}

Xia, Fan ^{[1
]}

机构：

[1] China Univ Geosci, Fac Mat Sci & Chem, State Key Lab Biogeol & Environm Geol, Wuhan 430074, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2022年 / 17卷 / 18期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

lifetime; probe; imaging; detection; biological analysis; FLUORESCENCE LIFETIME; IMAGING MICROSCOPY; IN-VIVO; VISCOSITY; CELLS; RELEASE;

D O I：

10.1002/asia.202200563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the development of modern biomedicine, biological analysis and detection are very important in disease diagnosis, detection of curative effect, prognosis and prediction of tumor recurrence. Compared with the currently widely used optical probes based on intensity signals, the lifetime signal does not depend on the influence of conditions such as the concentration of luminophore, tissue penetration depth and measurement method. Therefore, biological detection methods based on lifetime-based responsive probes have attracted great attention from the scientific community. Here, we briefly review the key advances in lifetime-based responsive probes in recent years (2017-2022). The review focuses on the design strategies of lifetime-based responsive probes and the research progress of their applications in the field of bioanalysis, and discusses the challenges they face. We hope it will further promote the development of lifetime-based responsive probes in the field of bioanalysis.

引用

页数：13

共 83 条

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