Interleukin-23 and Th17 cells in transplantation immunity: Does 23+17 equal rejection?

被引：46
|
作者：
Chen, Ye [1 ]
Wood, Kathryn J. [1 ]
机构：
[1] Univ Oxford, Transplant Res Immunol Grp, Nuffield Dept Surg, Oxford, England
来源：
TRANSPLANTATION | 2007年 / 84卷 / 09期
关键词：
IL-17; IL-23; IL-6; TGF beta; IL-12; interferon gamma; cytokine; transplantation; rejection; tolerance; allograft; ischemia reperfusion injury; Th17; Th1; Th2; ROR gamma T;
D O I：
10.1097/01.tp.0000287126.12083.48
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-23 (IL-23) and the recently discovered Th17 cells have been implicated in the pathogenesis of autoimmune diseases. This review will discuss current understanding of T-cell subsets in transplantation immunity and will explore the role of IL-23 and Th 17 cells in allograft rejection, tolerance, and ischemia reperfusion injury.
引用
收藏
页码：1071 / 1074
页数：4
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