Obstructive sleep apnea in children with nonsyndromic cleft palate: a systematic review

被引:3
作者
Jungbauer, W. Nicholas [1 ]
Poupore, Nicolas S. [1 ]
Nguyen, Shaun A. [1 ]
Carroll, William W. [1 ]
Pecha, Phayvanh P. [1 ]
机构
[1] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC550, Charleston, SC 29425 USA
来源
JOURNAL OF CLINICAL SLEEP MEDICINE | 2022年 / 18卷 / 08期
关键词
cleft palate; palatoplasty; pediatric; obstructive sleep apnea; apnea-hypopnea index; POLYSOMNOGRAPHIC FINDINGS; UPPER AIRWAY; LIP; INFANTS; ASSOCIATION; PREVALENCE;
D O I
10.5664/jcsm.10020
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: To characterize obstructive sleep apnea in children with nonsyndromic cleft palate based on polysomnographic parameters relative to primary palatoplasty. Methods: A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following databases were searched: PubMed, Scopus, CINAHL, and Cochrane. Studies were only considered for inclusion if they examined exclusively patients with nonsyndromic cleft palate and reported polysomnogram data. Results: Seven studies met inclusion criteria, providing information on a total of 151 patients with a weighted mean age of 5.2 +/- 5.0 years (range 0.1-12 years). Five studies presented data from either the pre- or postoperative period. Two studies investigated both pre- and postpalatoplasty polysomnogram data, and neither observed a significant change in apnea-hypopnea index (AHI) values following surgery (mean preoperative AHI of 2.7 events/h, mean improvement of 0.6 events/h). The entire cohort had a prepalatoplasty weighted mean AHI of 11.4 events/h (range 1.5-16.1) and postpalatoplasty AHI of 1.5 events/h (range 0.2-5.2). Interpretation of polysomnographic data was limited by heterogeneity; however, the AHI values for children with nonsyndromic cleft palate largely demonstrated mild to moderate obstructive sleep apnea following palatoplasty. Conclusions: The full effect of cleft palate repair on obstructive sleep apnea in children with nonsyndromic cleft palate remains understudied. While published data are heterogenous, few studies support the worsening of obstructive AHI after palatoplasty in children with nonsyndromic cleft palate. Further studies with standardized polysomnographic parameters are needed to provide guidance for management of this population.
引用
收藏
页码:2063 / 2068
页数:6
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