Combination of radiation therapy-immunotherapy for head and neck cancers: Promises kept?

被引：2
作者：
Huguet, F. [1 ]
Durand, B. [1 ]
Atallah, S. [2 ]
Prebet, C. [3 ]
Richard, S. [3 ]
Baujat, B. [2 ]
机构：
[1] Hop Tenon, Serv Oncol Radiotherapie, 4 Rue Chine, F-75020 Paris, France
[2] Serv Oto Rhino Laryngol Chirurg Cerv Faciale, Paris, France
[3] Sorbonne Univ, Serv Oncol Med, Hop Tenon, AP HP, Paris, France
来源：
CANCER RADIOTHERAPIE | 2021年 / 25卷 / 08期
关键词：
Head and neck cancer; Squamous cell carcinoma; Radiotherapy; Chemoradiotherapy; Cisplatin; Immunotherapy; Immune checkpoint inhibitors; PDL1; PD1; Abscopal effect; SQUAMOUS-CELL CARCINOMA; RADIOTHERAPY; CHEMOTHERAPY; NIVOLUMAB; CETUXIMAB; CHEMORADIOTHERAPY; RECURRENT; IMMUNITY; SAFETY; PHASE;
D O I：
10.1016/j.canrad.2021.08.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chemoradiotherapy with concurrent cisplatin has been the standard treatment for locally advanced headand neck squamous cell carcinoma (HNSCC) for over 20 years. Recently, immunotherapy, a new therapeutic class, has emerged for patients with recurrent or metastatic HNSCC and has significantly extendedtheir survival. Will it bring the same benefit to patients with localized tumors? There is a strong rationale for combining radiation therapy and checkpoint inhibitors for HNSCC. Indeed, radiation therapy canhave both immunostimulatory and immunomodulatory effects. This is what explains the famous abscopal effect. The aim of this review is to present the data available on the combination of radiation therapyand immunotherapy for HNSCC. (c) 2021 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. Allrights reserved.
引用
收藏
页码：811 / 815
页数：5
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