Advances in nanomedicine for the treatment of Alzheimer's and Parkinson's diseases

被引：32

作者：

Hernando, Sara ^{[1
,2
]}

Gartziandia, Oihane ^{[1
,2
]}

Herran, Enara ^{[1
,2
]}

Luis Pedraz, Jose ^{[1
,2
]}

Igartua, Manoli ^{[1
,2
]}

Maria Hernandez, Rosa ^{[1
,2
]}

机构：

[1] Univ Basque Country, UPV EHU, Sch Pharm, Lab Pharmaceut,NanoBioCel Grp, Vitoria 01006, Spain

[2] Biomed Res Networking Ctr Bioengn Biomat & Nano, Vitoria 01006, Spain

来源：

NANOMEDICINE | 2016年 / 11卷 / 10期

关键词：

Alzheimer's disease; drug delivery systems; nanomedicine; nanotechnology; Parkinson's disease; SOLID LIPID NANOPARTICLES; BLOOD-BRAIN-BARRIER; SUBCHRONIC INTRAMUSCULAR TOXICITY; LEVODOPA METHYL ESTER/BENSERAZIDE; ROTIGOTINE-LOADED MICROSPHERES; ADENOASSOCIATED VIRAL VECTORS; FIBROBLAST-GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; APP/PS1 MOUSE MODEL; NEUROTROPHIC FACTOR;

D O I：

10.2217/nnm-2016-0019

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases worldwide. Despite all the efforts made by the scientific community, current available treatments have limited effectiveness, without halting the progression of the disease. That is why, new molecules such as growth factors, antioxidants and metal chelators have been raised as new therapeutical approaches. However, these molecules have difficulties to cross the blood-brain barrier limiting its therapeutic effect. The development of nanometric drug delivery systems may permit a targeted and sustained release of old and new treatments offering a novel strategy to treat these neurodegenerative disorders. This review summarized the main investigated drug delivery systems as promising approaches to treat Alzheimer's disease and Parkinson's disease.

引用

页码：1267 / 1285

页数：19

共 105 条

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