Enhanced endothelium-independent vasodilator response to calcitonin gene-related peptide in hypertensive rats

被引：7

作者：

Tomobe, YI ^{[1
]}

Ishikawa, T ^{[1
]}

Goto, K ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 351卷 / 03期

关键词：

CGRP (calcitonin gene-related peptide); spontaneously hypertensive rat (SHR); mesenteric artery;

D O I：

10.1016/S0014-2999(98)00379-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In isolated superior mesenteric arteries, vasodilation induced by calcitonin gene-related peptide (CGRP) was significantly larger in 12-week-old spontaneously hypertensive rats (SHR) than Wistar-Kyoto rats (WKY). In WKY and 6-week-old SHR, most of the vasodilator response to CGRP was abolished by NW-nitro-L-arginine and indomethacin. In contrast, the inhibitors caused no significant change in the response in 12-week-old SHR. Vasodilations induced by acetylcholine and isoproterenol were smaller in 12-week-old SHR than WKY, and that induced by sodium nitroprusside was comparable in both tissues. These results suggest that endothelium-independent vasodilator activity of CGRP is enhanced in hypertensive SHR, which overwhelms the decreased endothelium-dependent effects. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：351 / 355

页数：5

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