Effect of parathyroid hormone on rat skeletal muscle in vivo

被引：0
作者：
Thompson, CH
Kemp, GJ
Radda, GK
机构：
[1] MRC Biochemical and Clinical Magnetic Resonance Unit, Oxford Radcliffe Hospital, Oxford
来源：
NEPHRON | 1996年 / 72卷 / 02期
关键词：
nuclear magnetic resonance spectroscopy; parathyroid hormone; phosphate; skeletal muscle metabolism; rat;
D O I：
10.1159/000188850
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The secondary hyperparathyroidism of chronic renal failure has been implicated in the pathogenesis of metabolic abnormalities in skeletal muscle. We studied the muscle metabolism in a model of hyperparathyroidism (Wistar rats injected with parathyroid hormone or saline for 4 days). P-31 magnetic resonance spectroscopy allowed measurements of the concentration of cytosolic metabolically active inorganic phosphate [Pi] at rest and the rates of oxidative and anaerobic adenosine triphosphate turnover during exercise and recovery. Parathyroid hormone caused significant reductions in plasma [Pi] and intracellular [Pi], but had no effect upon oxidative or glycogenolytic adenosine triphosphate turnover.
引用
收藏
页码：253 / 256
页数：4
相关论文
共 28 条
[1]   INVESTIGATION OF HUMAN MITOCHONDRIAL MYOPATHIES BY PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY [J].
ARNOLD, DL ;
TAYLOR, DJ ;
RADDA, GK .
ANNALS OF NEUROLOGY, 1985, 18 (02) :189-196
[2]   EFFECT OF PARATHYROID-HORMONE ON ENERGY-METABOLISM OF SKELETAL-MUSCLE [J].
BACZYNSKI, R ;
MASSRY, SG ;
MAGOTT, M ;
ELBELBESSI, S ;
KOHAN, R ;
BRAUTBAR, N .
KIDNEY INTERNATIONAL, 1985, 28 (05) :722-727
[3]  
BERGMEYER HU, 1974, METHOD ENZYMAT AN, P2101
[4]   A STUDY OF INTRACELLULAR ORTHO-PHOSPHATE CONCENTRATION IN HUMAN-MUSCLE AND ERYTHROCYTES BY P-31 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY AND SELECTIVE CHEMICAL-ASSAY [J].
BEVINGTON, A ;
MUNDY, KI ;
YATES, AJP ;
KANIS, JA ;
RUSSELL, RGG ;
TAYLOR, DJ ;
RAJAGOPALAN, B ;
RADDA, GK .
CLINICAL SCIENCE, 1986, 71 (06) :729-735
[5]  
BEVINGTON A, 1990, METABOLIC MOL BASIS, P1097
[6]   IMPAIRED ENERGY-METABOLISM IN SKELETAL-MUSCLE DURING PHOSPHATE-DEPLETION [J].
BRAUTBAR, N ;
CARPENTER, C ;
BACZYNSKI, R ;
KOHAN, R ;
MASSRY, SG .
KIDNEY INTERNATIONAL, 1983, 24 (01) :53-57
[7]  
BRAUTBAR N, 1983, KIDNEY INT S16, V24, P81
[8]   DEFECTIVE ADENOSINE-TRIPHOSPHATE SYNTHESIS - AN EXPLANATION FOR SKELETAL-MUSCLE DYSFUNCTION IN PHOSPHATE-DEFICIENT MICE [J].
HETTLEMAN, BD ;
SABINA, RL ;
DREZNER, MK ;
HOLMES, EW ;
SWAIN, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (02) :582-589
[9]   DECREASED LUMINAL MEMBRANE-TRANSPORT OF PHOSPHATE IN CHRONIC-RENAL-FAILURE [J].
HRUSKA, KA ;
KLAHR, S ;
HAMMERMAN, MR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 242 (01) :F17-F22
[10]   PROTON EFFLUX FROM RAT SKELETAL-MUSCLE INVIVO - CHANGES IN HYPERTENSION [J].
KEMP, GJ ;
THOMPSON, CH ;
RADDA, GK .
CLINICAL SCIENCE, 1992, 82 (05) :489-491
123