Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson's Disease

被引：24

作者：

Doppler, Kathrin ^{[1
]}

机构：

[1] Univ Hosp Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany

来源：

JOURNAL OF PARKINSONS DISEASE | 2021年 / 11卷 / 03期

关键词：

Parkinson's disease; synucleinopathy; skin; alpha-synuclein; SLEEP BEHAVIOR DISORDER; GLAND NEEDLE-BIOPSY; SKIN BIOPSY; COLONIC BIOPSIES; DIAGNOSIS; PATHOLOGY; DENERVATION; CRITERIA; NERVES;

D O I：

10.3233/JPD-202489

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alpha-synuclein deposits are detectable in skin biopsies of patients with Parkinson's disease and other synucleinopathies like multiple system atrophy by immunohistochemical staining. As they are easily to obtain, they appear a promising tool for the pre-mortem histopathological confirmation of the disease and as a potential outcome measure in studies targeting alpha-synuclein aggregates. Good sensitivity, specificity, and practicability are the most important requirements of a biomarker. The review gives an overview on all three aspects, addresses methodological problems and the lack of standardized procedures as a major problem and gives an outlook on the future of skin biopsy as a potential diagnostic tool in synucleinopathies.

引用

页码：937 / 947

页数：11

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