Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits

被引：28
作者：
Li, L.
Kong, X.
Liu, H.
Liu, C. [1 ]
机构：
[1] Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Peoples R China
[2] Shandong Univ, Sch Med, Key Lab Neurobiol, Jinan 250012, Peoples R China
[3] Heze Med Coll, Dept Physiol, Heze, Peoples R China
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2007年 / 19卷 / 10期
关键词：
gastrointestinal motility; oxytocin; receptor; vasopressin;
D O I：
10.1111/j.1365-2982.2007.00953.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The aim of the present study was to investigate the effect of systemic oxytocin (OT) and vasopressin (VP) on the motility of stomach and duodenum. Two plastic balloons made of condom were inserted into stomach and duodenum to monitor the change of mean pressure. Intravenous injection of OT (0.1-0.8 mu g kg(-1)) or VP (0.02-0.08 IU kg(-1)) dose-dependently increased the stomach and duodenum pressure. Pretreatment of atosiban (1 mu g kg(-1)), the specific OT receptor (OTR) antagonist, attenuated the excitatory effect of OT or VP on the pressure of stomach and duodenum. Pretreatment of V1880 (1 mu g kg(-1)), the specific V1 receptor blocker, did not influence this effect. So we conclude that both of OT and VP injected systemically increased the gastric and duodenum motility via OTR.
引用
收藏
页码：839 / 844
页数：6
相关论文
共 24 条
[1]   Structural bases of vasopressin/oxytocin receptor function [J].
Barberis, C ;
Mouillac, B ;
Durroux, T .
JOURNAL OF ENDOCRINOLOGY, 1998, 156 (02) :223-229
[2]   Vasopressin: Mechanisms of action on the vasculature in health and in septic shock [J].
Barrett, Lucinda K. ;
Singer, Mervyn ;
Clapp, Lucie H. .
CRITICAL CARE MEDICINE, 2007, 35 (01) :33-40
[3]   Hypophysectomy and neurointermediate pituitary lobectomy reduce serum immunoglobulin M (IgM) and IgG and intestinal IgA responses to Salmonella enterica serovar typhimurium infection in rats [J].
Campos-Rodríguez, R ;
Quintanar-Stephano, A ;
Jarillo-Luna, RA ;
Oliver-Aguillón, G ;
Ventura-Juárez, J ;
Rivera-Aguilar, V ;
Berczi, I ;
Kovacs, K .
INFECTION AND IMMUNITY, 2006, 74 (03) :1883-1889
[4]   BIOSYNTHESIS OF VASOPRESSIN BY GASTROINTESTINAL CELLS OF BRATTLEBORO AND LONG-EVANS RATS [J].
FRIEDMANN, AS ;
MEMOLI, VA ;
YU, XM ;
NORTH, WG .
PEPTIDES, 1993, 14 (03) :607-612
[5]   Postnatal oxytocin treatment and postnatal stroking of rats reduce blood pressure in adulthood [J].
Holst, S ;
Uvnäs-Moberg, K ;
Petersson, M .
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2002, 99 (02) :85-90
[6]   Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism [J].
Iseri, SÖ ;
Sener, G ;
Saglam, B ;
Gedik, N ;
Ercan, F ;
Yegen, BÇ .
PEPTIDES, 2005, 26 (03) :483-491
[7]   V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity [J].
Koshimizu, Taka-aki ;
Nasa, Yoshihisa ;
Tanoue, Akito ;
Oikawa, Ryo ;
Kawahara, Yuji ;
Kiyono, Yasushi ;
Adachi, Tetsuya ;
Tanaka, Toshiki ;
Kuwaki, Tomoyuki ;
Mori, Toyoki ;
Takeo, Satoshi ;
Okamura, Hitoshi ;
Tsujimoto, Gozoh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (20) :7807-7812
[8]  
Liu CY, 2003, CHINESE J PHYSIOL, V46, P95
[9]  
Liu CY, 2002, WORLD J GASTROENTERO, V8, P338
[10]  
LOPEZBERNAL A, 1989, BRIT J OBSTET GYNAEC, V96, P1108
123