Quantitative trait loci in Drosophila

被引：298
作者：
Mackay, TFC [1 ]
机构：
[1] N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
来源：
NATURE REVIEWS GENETICS | 2001年 / 2卷 / 01期
关键词：
D O I：
10.1038/35047544
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been accomplished for some quantitative trait loci in Drosophila. Drosophila quantitative trait loci have sex-, environment-and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes. These observations offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans.
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页码：11 / 20
页数：10
相关论文
共 81 条
[1]   The genome sequence of Drosophila melanogaster [J].
Adams, MD ;
Celniker, SE ;
Holt, RA ;
Evans, CA ;
Gocayne, JD ;
Amanatides, PG ;
Scherer, SE ;
Li, PW ;
Hoskins, RA ;
Galle, RF ;
George, RA ;
Lewis, SE ;
Richards, S ;
Ashburner, M ;
Henderson, SN ;
Sutton, GG ;
Wortman, JR ;
Yandell, MD ;
Zhang, Q ;
Chen, LX ;
Brandon, RC ;
Rogers, YHC ;
Blazej, RG ;
Champe, M ;
Pfeiffer, BD ;
Wan, KH ;
Doyle, C ;
Baxter, EG ;
Helt, G ;
Nelson, CR ;
Miklos, GLG ;
Abril, JF ;
Agbayani, A ;
An, HJ ;
Andrews-Pfannkoch, C ;
Baldwin, D ;
Ballew, RM ;
Basu, A ;
Baxendale, J ;
Bayraktaroglu, L ;
Beasley, EM ;
Beeson, KY ;
Benos, PV ;
Berman, BP ;
Bhandari, D ;
Bolshakov, S ;
Borkova, D ;
Botchan, MR ;
Bouck, J ;
Brokstein, P .
SCIENCE, 2000, 287 (5461) :2185-2195
[2]  
Anholt RRH, 1996, GENETICS, V143, P293
[3]  
[Anonymous], 1998, Genetics and Analysis of Quantitative Traits (Sinauer)
[4]  
AQUADRO CF, 1986, GENETICS, V114, P1165
[5]  
AQUADRO CF, 1992, GENETICS, V132, P443
[6]  
Ashburner M, 1999, GENETICS, V153, P179
[7]  
Ashburner M., 1989, LAB HDB
[8]  
BREESE E. L., 1957, HEREDITY, V11, P373, DOI 10.1038/hdy.1957.30
[9]   Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].
不详 .
SCIENCE, 1998, 282 (5396) :2012-2018
[10]  
Campos-Ortega J, 1993, DEV DROSOPHILA MELAN, V2, P1091
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