Surface grafting of PEO-Based star-shaped molecules for bioanalytical and biomedical applications

被引：92

作者：

Gasteier, Peter

Reska, Anna

Schulte, Petra

Salber, Jochen

Offenhaeusser, Andreas

Moeller, Martin

Groll, Juergen

机构：

[1] Rhein Westfal TH Aachen, DWI, D-52074 Aachen, Germany

[2] Forschungszentrum Julich, Inst Thin Films & Interfaces, Julich, Germany

[3] SusTech Gmbh & Co KG, D-64287 Darmstadt, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2007年 / 7卷 / 08期

关键词：

bio compatibility; functionality; hydrogel coating; molecular recognition; PEO star polymers;

D O I：

10.1002/mabi.200700064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article reviews surface grafting of star-shaped PEO. The use of star-shaped polymers is compared to linear PEO chains regarding the layer preparation and the ability of the resulting surfaces to resist protein adsorption. We then focus on the use of end-functionalized, star-shaped, PEO-based prepolymers that are able to form covalent crosslinks and functional polymer networks on the substrate. Examples are given for specific protein adsorption as well as for cell adhesion on such layers by covalent embedding of biofunctional molecules. The possibility of coating biomedically relevant polymer substrates in three-dimensional geometries is discussed and examples are shown for poly(ethylene terephthalate) monofilament constructs.

引用

页码：1010 / 1023

页数：14

共 90 条

[1] Hydrogel networks of poly(ethylene oxide) star-molecules supported by expanded polytetrafluoroethylene membranes: Characterization, biocompatibility evaluation and glucose diffusion characteristics [J].