Enantioselective synthesis of 2,2-difluoro-3-hydroxycarboxylates by rhodium-catalyzed hydrogenation

被引：37
|
作者：
Kuroki, Y [1 ]
Asada, D [1 ]
Iseki, K [1 ]
机构：
[1] Daikin Ind Ltd, Div Chem, Tsukuba, Ibaraki 3050841, Japan
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 50期
关键词：
asymmetric synthesis; catalysts; fluorine and compounds; hydrogenation;
D O I：
10.1016/S0040-4039(00)01744-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The highly enantioselective synthesis of 2,2-difluoro-3 -hydroxycarboxylates has been achieved by hydrogenating 2,2-difluoro-3-oxocarboxylates in the presence of chiral rhodium-(amidephosphine-phosphinite) complexes. Ethyl 4,4,4-triffluoroacetoacetate can be successfully transformed into the enantiomerically enriched 4,4,4-trifluoro-3-hydroxybutanoate in the same manner. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9853 / 9858
页数：6
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