Voltammetric behaviour of mitoxantrone at a DNA-biosensor

被引：101
|
作者：
Brett, AMO [1 ]
Macedo, TRA
Raimundo, D
Marques, MH
Serrano, SHP
机构：
[1] Univ Coimbra, Dept Quim, Fac Ciencias & Tecnol, P-3000 Coimbra, Portugal
[2] Univ Coimbra, Fac Med, P-3000 Coimbra, Portugal
[3] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo, Brazil
来源：
BIOSENSORS & BIOELECTRONICS | 1998年 / 13卷 / 7-8期
关键词：
bioelectrochemistry; DNA interaction; mitoxantrone; DNA-biosensor; voltammetry;
D O I：
10.1016/S0956-5663(98)00053-0
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The surface of an electrochemical glassy carbon electrode was modified with a layer of double-stranded DNA (dsDNA) or with double-stranded DNA conditioned in single-stranded DNA (ssDNA) and was used to investigate mitoxantrone-DNA interactions. Differential pulse and square wave voltammetry were applied to develop an electroanalytical procedure for the determination of mitoxantrone and evaluate its interaction with dsDNA or ssDNA immobilized on the electrode surface. The results demonstrate that MTX interaction with DNA is not specific to either guanine or adenine bases. The kinetics of the mitoxantrone-DNA interaction is slow and damage to DNA was followed with time. (C) 1998 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：861 / 867
页数：7
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