Genomic and proteomic approaches for Chagas' disease:: critical analysis of diagnostic methods

被引：4
作者：
Huete-Pérez, JA
Flores-Obando, RE
Ghedin, E
Caffrey, CR
机构：
[1] Univ Calif San Francisco, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94143 USA
[2] Univ Cent Amer, Ctr Biol Mol, Managua, Nicaragua
[3] Inst Genom Res, Rockville, MD 20850 USA
来源：
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2005年 / 5卷 / 04期
关键词：
Chagas' disease; diagnosis; genomics; microarray; proteomics; transcriptomics;
D O I：
10.1586/14737159.5.4.521
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Trypanosoma cruzi is the etiologic agent of Chagas' disease, a chronic inflammatory condition that results in heart and digestive complications. The first draft of the parasite genome is now complete and it is expected that, along with the published genomic and proteomic analyses discussed herein, it will lead to the identification of crucial genes and proteins directly associated with disease. This article reviews the current research trends addressing host-parasite interaction, parasite genetic variability and diagnosis. These advances will certainly bring about major developments not only in our understanding of Trypanosoma cruzi biology, but also in the application of new technologies to disease prevention and control.
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收藏
页码：521 / 530
页数：10
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