Apatinib for the treatment of gastric cancer

被引：95

作者：

Roviello, Giandomenico ^{[1
,2
]}

Ravelli, Andrea ^{[3
]}

Fiaschi, Anna Ida ^{[4
]}

Cappelletti, Maria Rosa ^{[2
]}

Gobbi, Angela ^{[2
]}

Senti, Chiara ^{[2
]}

Zanotti, Laura ^{[2
]}

Polom, Karol ^{[5
,6
]}

Reynolds, Andrew R. ^{[7
]}

Fox, Stephen B. ^{[8
]}

Generali, Daniele ^{[2
,9
]}

机构：

[1] Univ Brescia, Dept Mol & Translat Med, Viale Europa 11, I-25124 Brescia, Italy

[2] ASST Cremona, Unit Mol Therapy & Pharmacogen, Cremona, Italy

[3] Univ Parma, Sect Expt Oncol, Dept Clin & Expt Med, Parma, Italy

[4] Univ Siena, Pharmacol Unit, Siena, Italy

[5] Univ Siena, Dept Med Surg & Neurosci, Siena, Italy

[6] Univ Siena, Unit Gen & Minimally Invas Surg, Siena, Italy

[7] Inst Canc Res, Breast Canc Now Res Ctr, Tumour Biol Team, London, England

[8] Univ Melbourne, Dept Pathol, Peter Mac Callum Canc Ctr, Melbourne, Vic, Australia

[9] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2016年 / 10卷 / 08期

关键词：

Gastric cancer; apatinib; VEGFR2; angiogenesis; chemotherapy; ENDOTHELIAL GROWTH-FACTOR; FACTOR RECEPTOR-2; DOUBLE-BLIND; SUPPORTIVE CARE; PHASE-II; CHEMOTHERAPY; INHIBITOR; VEGF; PHARMACOKINETICS; EPIRUBICIN;

D O I：

10.1080/17474124.2016.1209407

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction: Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor 2, has demonstrated encouraging anti-cancer activity in gastric cancer within both in vitro and in vivo models.Areas covered: Apatinib's efficacy, tolerability and safety have been evaluated in one Phase II and one Phase III study in metastatic/advanced gastric cancer. In this review, we focus on the mechanism of action of apatinib, its pharmacokinetic profile and its clinical activity in the treatment of advanced/metastatic gastric cancer.Expert commentary: Unfortunately, as yet, there is no definitive biomarker data for apatinib in gastric cancer.

引用

页码：887 / 892

页数：6

共 35 条

[1]

[Anonymous], P AM ASS CANC RES

[2] Angiogenic inhibitors in gastric cancers and gastroesophageal junction carcinomas: A critical insight [J].

Aprile, Giuseppe ;

Ongaro, Elena ;

Del Re, Marzia ;

Lutrino, Stefania Eufemia ;

Bonotto, Marta ;

Ferrari, Laura ;

Rihawi, Karim ;

Cardellino, Giovanni Gerardo ;

Pella, Nicoletta ;

Danesi, Romano ;

Fasola, Gianpiero .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2015, 95 (02) :165-178

[3]

Bang YJ, 2010, LANCET, V376, P1302

[4] Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[5] HER2 therapies and gastric cancer: A step forward [J].

de Mello, Ramon Andrade ;

Marques, Andrea Marin ;

Araujo, Antonio .

WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (37) :6165-6169

[6] Metabolism and Pharmacokinetics of Novel Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitor Apatinib in Humans [J].

Ding, Juefang ;

Chen, Xiaoyan ;

Gao, Zhiwei ;

Dai, Xiaojian ;

Li, Liang ;

Xie, Cen ;

Jiang, Haoyuan ;

Zhang, Lijia ;

Zhong, Dafang .

DRUG METABOLISM AND DISPOSITION, 2013, 41 (06) :1195-1210

[7] Phosphorylated VEGFR2 and hypertension: potential biomarkers to indicate VEGF-dependency of advanced breast cancer in anti-angiogenic therapy [J].

Fan, Minhao ;

Zhang, Jian ;

Wang, Zhonghua ;

Wang, Biyun ;

Zhang, Qunlin ;

Zheng, Chunlei ;

Li, Ting ;

Ni, Chen ;

Wu, Zhenhua ;

Shao, Zhimin ;

Hu, Xichun .

BREAST CANCER RESEARCH AND TREATMENT, 2014, 143 (01) :141-151

[8] Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 [J].

Ferlay, Jacques ;

Soerjomataram, Isabelle ;

Dikshit, Rajesh ;

Eser, Sultan ;

Mathers, Colin ;

Rebelo, Marise ;

Parkin, Donald Maxwell ;

Forman, David ;

Bray, Freddie .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E359-E386

[9] Vascular endothelial growth factor as a target for anticancer therapy [J].

Ferrara, N .

ONCOLOGIST, 2004, 9 :2-10

[10] The biology of VEGF and its receptors [J].

Ferrara, N ;

Gerber, HP ;

LeCouter, J .

NATURE MEDICINE, 2003, 9 (06) :669-676

← 1 2 3 4 →