5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma

被引:26
作者
Cheng, Jeffrey P. [1 ,2 ]
Leary, Jacob B. [1 ,2 ,7 ]
Sembhi, Aerin [1 ]
Edwards, Clarice M. [1 ,2 ]
Bondi, Corina O. [1 ,2 ,5 ]
Kline, Anthony E. [1 ,2 ,3 ,4 ,5 ,6 ]
机构
[1] Univ Pittsburgh, Phys Med & Rehabil, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Psychol, Pittsburgh, PA 15213 USA
[4] Univ Pittsburgh, Crit Care Med, Pittsburgh, PA 15213 USA
[5] Univ Pittsburgh 1letab, Ctr Neurosci, Pittsburgh, PA 15213 USA
[6] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA
[7] NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA
关键词
5-HT1A receptor agonists; Behavioral outcome; Controlled cortical impact; Functional recovery; Hippocampus; Learning and memory; Morris water maze; Serotonin(1A); Traumatic brain injury; CORTICAL IMPACT INJURY; BAY X 3702; ENVIRONMENTAL ENRICHMENT; METHYLPHENIDATE TREATMENT; NEUROBEHAVIORAL BENEFIT; MODERATE HYPOTHERMIA; BEHAVIORAL RECOVERY; COGNITIVE FUNCTION; TREATMENT REGIMEN; CLINICAL-TRIALS;
D O I
10.1016/j.brainres.2015.11.026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Traumatic brain injury (TBI) is a significant and enduring health care issue with limited treatment options. While several pre-clinical therapeutic approaches have led to enhanced motor and/or cognitive performance, the benefits of these treatments have not translated to the clinic. One plausible explanation is that the therapies may not have been rigorously evaluated, thus rendering the bench-to-bedside leap premature and subsequently unsuccessful. An approach that has undergone considerable empirical research after TBI is pharmacological targeting of 5-HT1A receptors with agonists such as repinotan HCl, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), and buspirone. The goal of this review is to integrate and interpret the findings from a series of studies that evaluated the efficacy of 5-HT1A receptor agonists on functional, histological, and molecular outcome after acquired brain injury. The overwhelming consensus of this exhaustive review is that a decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma. This article is part of a Special Issue entitled SI:Brain injury and recovery. (c) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:5 / 14
页数:10
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