Immunohistochemical assessment for Cdx2 expression in the Barrett metaplasia-dysplasia-adenocarcinoma sequence

被引：26

作者：

Hayes, Stephen ^{[1
]}

Ahmed, Sajad ^{[1
]}

Clark, Peter ^{[1
]}

机构：

[1] Salford Royal NHS Fdn Trust, Dept Histopathol, Salford M6 8HD, Lancs, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2011年 / 64卷 / 02期

关键词：

HOMEOBOX GENE; INTESTINAL DEVELOPMENT; ESOPHAGUS; DIAGNOSIS; MARKER; DIFFERENTIATION; PROGRESSION; EPITHELIUM; CANCER;

D O I：

10.1136/jcp.2010.075945

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background Barrett oesophagus (BO) occurs as a consequence of prolonged gastro-oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. Aims The aim of this study was to accurately assess Cdx2 expression in the oesophageal metaplasia-dysplasia-adenocarcinoma sequence. Method The expression of the transcription factor Cdx2 in Barrett metaplasia, high-grade glandular dysplasia and adenocarcinoma was investigated using immunohistochemistry. Results The results confirmed previous immunohistochemistry and PCR-based investigations, indicating that Cdx2 was expressed by intestinal metaplasia in the oesophagus. In addition, upregulation followed by linear downregulation of Cdx2 expression through the oesophageal metaplasia-dysplasia-adenocarcinoma sequence was demonstrated for the first time. Conclusion Such downregulation of Cdx2 expression could be in keeping with a role as a tumour suppressor gene, but a simpler explanation would be downregulation of a differentiation marker.

引用

页码：110 / 113

页数：4

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