The DNA Damage Response-Repair or Despair?

被引：36
作者：
Ljungman, Mats [1 ,2 ]
机构：
[1] Univ Michigan, Dept Radiat Oncol, Ctr Comprehens Canc, Div Radiat & Canc Biol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
来源：
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2010年 / 51卷 / 8-9期
关键词：
DNA repair; cell cycle checkpoints; apoptosis; aging; review; cancer; NUCLEOTIDE EXCISION-REPAIR; LIGHT-INDUCED APOPTOSIS; DOUBLE-STRAND BREAKS; MONOCHROMATIC ULTRAVIOLET-RADIATION; TRANSCRIPTION-COUPLED REPAIR; CELL-CYCLE REGULATION; LI-FRAUMENI SYNDROME; RNA-POLYMERASE-II; XERODERMA-PIGMENTOSUM; ESCHERICHIA-COLI;
D O I：
10.1002/em.20597
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The term "the DNA damage response" (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair. More recent discoveries of signal transduction pathways linking DNA damage to cell cycle arrest and apoptosis have greatly expanded our views of how cells and tissues limit mutagenesis and tumorigenesis. DNA repair not only plays a pivotal role in suppressing mutagenesis but also in the reversal of signals inducing the stress response. If repair is faulty or the cell is overwhelmed by damage, chances are that the cell will despair and be removed by apoptosis. This final fate is determined by intricate cellular dosimeters that are yet to be fully understood. Here, key findings leading to our current view of DDR are discussed as well as potential areas of importance for future studies. Environ. Mol. Mutagen. 51:879-889, 2010. (c) 2010 Wiley-Liss, Inc.
引用
收藏
页码：879 / 889
页数：11
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