Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

被引：78

作者：

Ogawa, AK

Willoughby, CA

Bergeron, R

Ellsworth, KP

Geissler, WM

Myers, RW

Yao, J

Harris, G

Chapman, KT

机构：

[1] Merck Res Labs, Dept Basic Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Metab Disorders Diabet, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

关键词：

LIVER;

D O I：

10.1016/S0960-894X(03)00798-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3405 / 3408

页数：4

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