Antileishmanial activity of a guaianolide from Tanacetum parthenium (L) Schultz Bip

被引：21

作者：

da Silva, Bruna Polacchine ^{[1
]}

Cortez, Diogenes Aparicio ^{[1
]}

Violin, Thaisa Yume ^{[1
]}

Dias Filho, Benedito Prado ^{[1
]}

Nakamura, Celso Vataru ^{[1
]}

Ueda-Nakamura, Tania ^{[1
]}

Piloto Ferreira, Izabel Cristina ^{[1
]}

机构：

[1] Univ Estadual Maringa, Programa Pos Grad Ciencias Farmaceut, Maringa, Parana, Brazil

来源：

PARASITOLOGY INTERNATIONAL | 2010年 / 59卷 / 04期

关键词：

Leishmania amazonensis; Antileishmanial activity; Tanacetum parthenium; Guaianolide; LEISHMANIASIS; PARTHENOLIDE;

D O I：

10.1016/j.parint.2010.08.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Leishmaniasis is one of the major infectious diseases affecting the poorest regions of the world The present study evaluated the antileishmanial activity of a guaianolide purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium (L.) Schultz Bip The isolated compound showed activity against the promastigote form of Leishmania amazonensis with 50% inhibition (IC50) of cell growth at a concentration of 2 6 mu g/ml For the intracellular amastigote form this guaianolide reduced by 10% the survival index of parasites in macrophages when it was used at 20 0 mu g/ml The selective index (SI) ratio (CC50 for J774G8 cells/IC50 for protozoans) was 385 showing that it is more selective against the parasite than mammalian cells Morphological alterations of protozoans treated with IC50 included changes in size shape and structure (more than one nucleus and flagellum) under both light and scanning electron microscopes (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：643 / 646

页数：4

共 11 条

[1]

Acosta J., 1993, J NAT PRODUCTS, V56, P90

[2] Effects of fluconazole on the pharmacokinetics and pharmacodynamics of antimony in cutaneous leishmaniasis-infected hamsters [J].

Alnaim, Lamya ;

Abou Alsoud, Nermeen ;

Zaghloul, Iman ;

Al-Jaser, May .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 (06) :728-732

[3] Cytotoxic activity of some natural and synthetic guaianolides [J].

Bruno, M ;

Rosselli, S ;

Maggio, A ;

Raccuglia, RA ;

Bastow, KF ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (07) :1042-1046

[4] Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine [J].

Coelho, Adriano C. ;

Gentil, Luciana G. ;

da Silveira, Jose Franco ;

Cotrim, Paulo C. .

EXPERIMENTAL PARASITOLOGY, 2008, 120 (01) :98-102

[5]

Croft SL, 2006, INDIAN J MED RES, V123, P399

[6] Drugs against leishmaniasis: a synergy of technology and partnerships [J].

Davis, AJ ;

Murray, HW ;

Handman, E .

TRENDS IN PARASITOLOGY, 2004, 20 (02) :73-76

[7] Leishmanial infection: Analysis of its first steps. A review [J].

de Almeida, MC ;

Vilhena, V ;

Barral, A ;

Barral-Netto, M .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2003, 98 (07) :861-870

[8] Parthenolide and its photochemically synthesized 1(10)Z isomer:: Chemical reactivity and structure-activity relationship studies in human leucocyte chemotaxis [J].

Neukirch, H ;

Kaneider, NC ;

Wiedermann, CJ ;

Guerriero, A ;

D'Ambrosio, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (07) :1503-1510

[9] Synthesis of biologically active guaianolides with a trans-annulated lactone moiety [J].

Schall, Andreas ;

Reiser, Oliver .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (14) :2353-2364

[10] Quantitative structure-activity relationship of sesquiterpene lactones with cytotoxic activity [J].

Scotti, Marcus T. ;

Fernandes, Mariane B. ;

Ferreira, Marcelo J. P. ;

Emerenciano, Vicente P. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (08) :2927-2934

← 1 2 →